Cell Biology Antibodies 10
Anti-SYP Antibody (CAB6344)
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- SKU:
- CAB6344
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SYP Antibody |
| Antibody SKU: | CAB6344 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SYP (NP_003170.1). |
| Application: | WB IHC IF IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, Mouse brain, Mouse eye, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SYP (NP_003170.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AFMW LVSS SAWA KGLS DVKM ATDP ENII KEMP VCRQ TGNT CKEL RDPV TSGL NTSV VFGF LNLV LWVG NLWF VFKE TGWA APFL RAPP GAPE KQPA PGDA Y |
| Gene ID: | 6855 |
| Uniprot: | P08247 |
| Cellular Location: | Cell junction, Cytoplasmic vesicle, Multi-pass membrane protein, secretory vesicle, synapse, synaptic vesicle membrane, synaptosome |
| Calculated MW: | 20kDa/33kDa |
| Observed MW: | 38kDa |
| Synonyms: | MRX96, MRXSYP, SYP |
| Background: | This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). |
| UniProt Protein Function: | SYP: Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity. Homohexamer or homotetramer. Interacts with SRCIN1. Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype. Belongs to the synaptophysin/synaptobrevin family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Vesicle; Membrane protein, integral Chromosomal Location of Human Ortholog: Xp11.23-p11.22 Cellular Component: cell junction; excitatory synapse; integral to synaptic vesicle membrane; neuron projection; presynaptic active zone; presynaptic membrane; synaptic vesicle; synaptic vesicle membrane; terminal button Molecular Function:cholesterol binding; identical protein binding; protein self-association; SH2 domain binding; transporter activity Biological Process: endocytosis; regulation of long-term neuronal synaptic plasticity; regulation of neuronal synaptic plasticity; regulation of short-term neuronal synaptic plasticity; synaptic vesicle maturation; synaptic vesicle membrane organization and biogenesis Disease: Mental Retardation, X-linked 96 |
| NCBI Summary: | This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011] |
| UniProt Code: | P08247 |
| NCBI GenInfo Identifier: | 135162 |
| NCBI Gene ID: | 6855 |
| NCBI Accession: | P08247.3 |
| UniProt Secondary Accession: | P08247,Q6P2F7, B2R7L6, B7Z359, |
| UniProt Related Accession: | P08247 |
| Molecular Weight: | 20,757 Da |
| NCBI Full Name: | Synaptophysin |
| NCBI Synonym Full Names: | synaptophysin |
| NCBI Official Symbol: | SYP |
| NCBI Official Synonym Symbols: | MRX96; MRXSYP |
| NCBI Protein Information: | synaptophysin |
| UniProt Protein Name: | Synaptophysin |
| UniProt Synonym Protein Names: | Major synaptic vesicle protein p38 |
| Protein Family: | Synaptophysin |
| UniProt Gene Name: | SYP |
| UniProt Entry Name: | SYPH_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SYP antibody (CAB6344) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
 | Immunohistochemistry of paraffin-embedded mouse pancreas using SYP Rabbit pAb (CAB6344) at dilution of 100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat pancreas using SYP Rabbit pAb (CAB6344) at dilution of 100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human appendix using SYP Rabbit pAb (CAB6344) at dilution of 100 (40x lens). |
 | Immunofluorescence analysis of C6 cells using SYP Rabbit pAb (CAB6344) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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