Cell Biology Antibodies 17
Anti-Syntenin Antibody (CAB5497)
- SKU:
- CAB5497
Description
| Antibody Name: | Anti-Syntenin Antibody |
| Antibody SKU: | CAB5497 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Syntenin |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse heart, Rat brain |
| Immunogen: | A synthesized peptide derived from human Syntenin |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6386 |
| Uniprot: | O00560 |
| Cellular Location: | |
| Calculated MW: | 32kDa |
| Observed MW: | 35KDa |
| Synonyms: | MDA-9, MDA9, ST1, SYCL, TACIP18 |
| Background: | The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017] |
| UniProt Protein Function: | syntenin: Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine; Adaptor/scaffold; Vesicle; Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 8q12 Cellular Component: extracellular space; endoplasmic reticulum membrane; focal adhesion; cytosol; adherens junction; cytoskeleton; membrane; cytoplasm; plasma membrane; melanosome; interleukin-5 receptor complex; nucleus; vesicle Molecular Function:syndecan binding; protein C-terminus binding; identical protein binding; protein homodimerization activity; ephrin receptor binding; protein N-terminus binding; protein binding; interleukin-5 receptor binding; protein heterodimerization activity; frizzled binding; neurexin binding; growth factor binding; cytoskeletal adaptor activity; cell adhesion molecule binding; glycoprotein binding Biological Process: synaptic transmission; axon guidance; Ras protein signal transduction; ephrin receptor signaling pathway; positive regulation of JNK cascade; actin cytoskeleton organization and biogenesis; protein targeting to membrane; substrate-bound cell migration, cell extension; positive regulation of phosphorylation |
| NCBI Summary: | The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017] |
| UniProt Code: | O00560 |
| NCBI GenInfo Identifier: | 20455281 |
| NCBI Gene ID: | 6386 |
| NCBI Accession: | O00560.1 |
| UniProt Related Accession: | O00560 |
| Molecular Weight: | |
| NCBI Full Name: | Syntenin-1 |
| NCBI Synonym Full Names: | syndecan binding protein |
| NCBI Official Symbol: | SDCBP |
| NCBI Official Synonym Symbols: | ST1; MDA9; SYCL; MDA-9; TACIP18 |
| NCBI Protein Information: | syntenin-1 |
| UniProt Protein Name: | Syntenin-1 |
| UniProt Synonym Protein Names: | Melanoma differentiation-associated protein 9; MDA-9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; TACIP18; Scaffold protein Pbp1; Syndecan-binding protein 1 |
| Protein Family: | High affinity sulfate transporter |
| UniProt Gene Name: | SDCBP |
| UniProt Entry Name: | SDCB1_HUMAN |
 | Western blot - Syntenin Rabbit mAb (CAB5497) |
Additional Information
Product Type: |
Antibody |
Reactivity: |
Human |
Reactivity: |
Mouse |
Reactivity: |
Rat |
Host Species: |
Rabbit |
Isotype: |
IgG |
Research Area: |
Cell Biology |
Related Products
Human Syntenin/SDCBP Recombinant Protein (RPES0493)
Human Syntenin 2 / SDCBP2 ELISA Kit
