Cell Biology Antibodies 11

Anti-Syntaxin-7 Antibody (CAB8057)

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SKU:
CAB8057
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:STX7 Rabbit Polyclonal Antibody
Antibody SKU:CAB8057
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human STX7 (NP_003560.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:U-251MG, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human STX7 (NP_003560.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSYT PGVG GDPA QLAQ RISS NIQK ITQC SVEI QRTL NQLG TPQD SPEL RQQL QQKQ QYTN QLAK ETDK YIKE FGSL PTTP SEQR QRKI QKDR LVAE FTTS LTNF QKVQ RQAA EREK EFVA RVRA SSRV SGSF PEDS SKER NLVS WESQ TQPQ VQVQ DEEI TEDD LRLI HE
Gene ID:8417
Uniprot:O15400
Cellular Location:Early endosome membrane, Single-pass type IV membrane protein
Calculated MW:27kDa/29kDa
Observed MW:40kDa
Synonyms:STX7
Background:The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome.
UniProt Protein Function:STX7: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. Belongs to the syntaxin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q23.1

Cellular Component: intracellular membrane-bound organelle; lysosomal membrane; lysosome; early endosome; integral to membrane; immunological synapse; endomembrane system; SNARE complex; azurophil granule; recycling endosome; endocytic vesicle; perinuclear region of cytoplasm; early endosome membrane; late endosome; plasma membrane; vesicle; endosome

Molecular Function:SNAP receptor activity; SNARE binding; chloride channel inhibitor activity; syntaxin binding

Biological Process: vesicle fusion; intracellular protein transport; organelle localization; vesicle docking; positive regulation of T cell mediated cytotoxicity

UniProt Code:O15400
NCBI GenInfo Identifier:20532414
NCBI Gene ID:8417
NCBI Accession:O15400.4
UniProt Secondary Accession:O15400,O70439,
UniProt Related Accession:O15400
Molecular Weight:261
NCBI Full Name:Syntaxin-7
NCBI Synonym Full Names:syntaxin 7
NCBI Official Symbol:STX7  
NCBI Protein Information:syntaxin-7
UniProt Protein Name:Syntaxin-7
Protein Family:Syntaxin
UniProt Gene Name:STX7  
UniProt Entry Name:STX7_HUMAN
Anti-Syntaxin-7 Polyclonal Antibody (CAB8057)Western blot analysis of extracts of various cell lines, using STX7 antibody (CAB8057) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-Syntaxin-7 Polyclonal Antibody (CAB8057)Immunohistochemistry of paraffin-embedded human stomach using STX7 antibody (CAB8057) at dilution of 1:100 (40x lens).
Anti-Syntaxin-7 Polyclonal Antibody (CAB8057)Immunohistochemistry of paraffin-embedded mouse kidney using STX7 antibody (CAB8057) at dilution of 1:100 (40x lens).
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