Signal Transduction Antibodies 3
Anti-Syntaxin-5 Antibody (CAB8455)
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- SKU:
- CAB8455
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-Syntaxin-5 Antibody |
| Antibody SKU: | CAB8455 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 55-355 of human STX5 (NP_003155.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 55-355 of human STX5 (NP_003155.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSCR DRTQ EFLS ACKS LQTR QNGI QTNK PALR AVRQ RSEF TLMA KRIG KDLS NTFA KLEK LTIL AKRK SLFD DKAV EIEE LTYI IKQD INSL NKQI AQLQ DFVR AKGS QSGR HLQT HSNT IVVS LQSK LASM SNDF KSVL EVRT ENLK QQRS RREQ FSRA PVSA LPLA PNHL GGGA VVLG AESH ASKD VAID MMDS RTSQ QLQL IDEQ DSYI QSRA DTMQ NIES TIVE LGSI FQQL AHMV KEQE ETIQ RIDE NVLG AQLD VEAA HSEI LKYF QSVT SNRW LMVK IFLI LIVF FIIF VVFL A |
| Gene ID: | 6811 |
| Uniprot: | Q13190 |
| Cellular Location: | Endoplasmic reticulum-Golgi intermediate compartment membrane, Golgi apparatus membrane, Single-pass type IV membrane protein |
| Calculated MW: | 29kDa/34kDa/35kDa/39kDa |
| Observed MW: | 45kDa |
| Synonyms: | STX5, SED5, STX5A |
| Background: | This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | STX5: Mediates endoplasmic reticulum to Golgi transport. Belongs to the syntaxin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 11q12.3 Cellular Component: endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; Golgi apparatus; Golgi membrane; integral to membrane; nucleoplasm; SNARE complex; vesicle Molecular Function:protein binding; protein N-terminus binding; SNAP receptor activity; SNARE binding Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; intracellular protein transport; positive regulation of protein catabolic process; retrograde transport, endosome to Golgi; vesicle docking; vesicle fusion |
| NCBI Summary: | This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q13190 |
| NCBI GenInfo Identifier: | 114152881 |
| NCBI Gene ID: | 6811 |
| NCBI Accession: | Q13190.2 |
| UniProt Secondary Accession: | Q13190,Q5U0D4, Q7Z3T6, Q9BUG1, B2R8T2, F8W8Q9, |
| UniProt Related Accession: | Q13190 |
| Molecular Weight: | 35,474 Da |
| NCBI Full Name: | Syntaxin-5 |
| NCBI Synonym Full Names: | syntaxin 5 |
| NCBI Official Symbol: | STX5 |
| NCBI Official Synonym Symbols: | SED5; STX5A |
| NCBI Protein Information: | syntaxin-5 |
| UniProt Protein Name: | Syntaxin-5 |
| Protein Family: | Syntaxin |
| UniProt Gene Name: | STX5 |
| UniProt Entry Name: | STX5_HUMAN |
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