Name: Anti-Syntaxin-11 Antibody (CAB8169)
Brand: Cell Biology Antibodies 12
SKU: CAB8169
Availability: OutOfStock

Antibody Name:	STX11 Rabbit Polyclonal Antibody
Antibody SKU:	CAB8169
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-287 of human STX11 (NP_003755.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse, Rat
Positive Samples:	Mouse lung, Rat lung

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-287 of human STX11 (NP_003755.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MKDR LAEL LDLS KQYD QQFP DGDD EFDS PHED IVFE TDHI LESL YRDI RDIQ DENQ LLVA DVKR LGKQ NARF LTSM RRLS SIKR DTNS IAKA IKAR GEVI HCKL RAMK ELSE AAEA QHGP HSAV ARIS RAQY NALT LTFQ RAMH DYNQ AEMK QRDN CKIR IQRQ LEIM GKEV SGDQ IEDM FEQG KWDV FSEN LLAD VKGA RAAL NEIE SRHR ELLR LESR IRDV HELF LQMA VLVE KQAD TLNV IELN VQKT VDYT GQAK AQVR KAVQ YEEK NPCR TLCC FCCP CLK
Gene ID:	8676
Uniprot:	O75558
Cellular Location:	Golgi apparatus, Membrane, Peripheral membrane protein, trans-Golgi network membrane
Calculated MW:	33kDa
Observed MW:	36kDa

Synonyms:	STX11, FHL4, HLH4, HPLH4
Background:	This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis.

UniProt Protein Function:	STX11: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. Defects in STX11 are the cause of familial hemophagocytic lymphohistiocytosis type 4 (FHL4); also known as HPLH4. Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous, rare autosomal recessive disorder. It is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits, and ataxia. Hemophagocytosis is a prominent feature of the disease, and a non-malignant infiltration of macrophages and activated T-lymphocytes in lymph nodes, spleen, and other organs is also found. Belongs to the syntaxin family.
UniProt Protein Details:	Chromosomal Location of Human Ortholog: 6q24.2 Cellular Component: integral to membrane; plasma membrane; SNARE complex; synaptic vesicle Molecular Function:protein binding; SNARE binding Biological Process: intracellular protein transport; synaptic vesicle fusion to presynaptic membrane; vesicle docking Disease: Hemophagocytic Lymphohistiocytosis, Familial, 4
NCBI Summary:	This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]
UniProt Code:	O75558
NCBI GenInfo Identifier:	6175047
NCBI Gene ID:	8676
NCBI Accession:	O75558.1
UniProt Secondary Accession:	O75558,O75378, O95148, Q5TCL6, E1P598,
UniProt Related Accession:	O75558
Molecular Weight:	33,196 Da
NCBI Full Name:	Syntaxin-11
NCBI Synonym Full Names:	syntaxin 11
NCBI Official Symbol:	STX11
NCBI Official Synonym Symbols:	FHL4; HLH4; HPLH4
NCBI Protein Information:	syntaxin-11
UniProt Protein Name:	Syntaxin-11
Protein Family:	Syntaxin
UniProt Gene Name:	STX11
UniProt Entry Name:	STX11_HUMAN

Anti-Syntaxin-11 Polyclonal Antibody (CAB8169)

Western blot analysis of extracts of various cell lines, using STX11 antibody (CAB8169) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 45s.

Antibodies

STX11 Antibody (PACO12554)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)