Cell Biology Antibodies 13
Anti-SYNJ1 Antibody (CAB17581)
- SKU:
- CAB17581
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SYNJ1 Antibody |
| Antibody SKU: | CAB17581 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human SYNJ1 (NP_003886.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | Jurkat, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human SYNJ1 (NP_003886.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GLLG VLRL NLGD TMLH YLVL VTGC MSVG KIQE SEVF RVTS TEFI SLRI DSSD EDRI SEVR KVLN SGNF YFAW SASG ISLD LSLN AHRS MQEQ TTDN RFFW N |
| Gene ID: | 8867 |
| Uniprot: | O43426 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 140kDa |
 | Western blot - SYNJ1 Polyclonal Antibody (CAB17581) |
| Synonyms: | EIEE53, INPP5G, PARK20, SYNJ1 |
| Background: | This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4, 5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Protein Function: | SYNJ1: Inositol 5-phosphatase which has a role in clathrin- mediated endocytosis. Belongs to the synaptojanin family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Phosphatase, lipid; EC 3.1.3.36; Carbohydrate Metabolism - inositol phosphate; Vesicle; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 21q22.2 Cellular Component: clathrin coat of coated pit; cytosol; membrane coat; microtubule; terminal button; vesicle membrane Molecular Function:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; phosphatidylinositol-3-phosphatase activity; phosphatidylinositol-4-phosphate phosphatase activity; phosphoinositide 5-phosphatase activity Biological Process: inositol phosphate dephosphorylation; inositol phosphate metabolic process; learning; neurotransmitter transport; phosphatidylinositol biosynthetic process; phosphatidylinositol metabolic process; phosphoinositide dephosphorylation; synaptic vesicle endocytosis; synaptic vesicle priming; synaptic vesicle transport; synaptic vesicle uncoating Disease: Parkinson Disease 20, Early-onset |
| NCBI Summary: | This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | O43426 |
| NCBI GenInfo Identifier: | 215273894 |
| NCBI Gene ID: | 8867 |
| NCBI Accession: | O43426.2 |
| UniProt Secondary Accession: | O43426,O43425, O94984, Q4KMR1, |
| UniProt Related Accession: | O43426 |
| Molecular Weight: | 58,068 Da |
| NCBI Full Name: | Synaptojanin-1 |
| NCBI Synonym Full Names: | synaptojanin 1 |
| NCBI Official Symbol: | SYNJ1 |
| NCBI Official Synonym Symbols: | INPP5G; PARK20 |
| NCBI Protein Information: | synaptojanin-1 |
| UniProt Protein Name: | Synaptojanin-1 |
| UniProt Synonym Protein Names: | Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1 |
| Protein Family: | Synaptojanin |
| UniProt Gene Name: | SYNJ1 |
| UniProt Entry Name: | SYNJ1_HUMAN |
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