Cell Biology Antibodies 17
Anti-Syndecan-1/CD138 Antibody (CAB4174)
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- SKU:
- CAB4174
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Syndecan-1/CD138 Antibody |
| Antibody SKU: | CAB4174 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Syndecan 1 |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HepG2, Mouse lung, Mouse kidney, Rat liver |
| Immunogen: | A synthesized peptide derived from human Syndecan 1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6382 |
| Uniprot: | P18827 |
| Cellular Location: | Membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 35kDa |
| Observed MW: | 90-100KDa/180-230KDa |
| Synonyms: | CD138, SDC, SYND1, syndecan |
| Background: | The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | syndecan-1: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Belongs to the syndecan proteoglycan family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Extracellular matrix Chromosomal Location of Human Ortholog: 2p24.1 Cellular Component: cell surface; cytoplasm; focal adhesion; Golgi lumen; integral to plasma membrane; lysosomal lumen; plasma membrane Molecular Function:protein binding; protein C-terminus binding Biological Process: cell migration; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; lipoprotein metabolic process; myoblast development; retinoid metabolic process; striated muscle cell development |
| NCBI Summary: | The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P18827 |
| NCBI GenInfo Identifier: | 229463011 |
| NCBI Gene ID: | 6382 |
| NCBI Accession: | P18827.3 |
| UniProt Secondary Accession: | P18827,Q53QV0, Q546D3, Q96HB7, D6W523, |
| UniProt Related Accession: | P18827,AAB21434,AAB23935 |
| Molecular Weight: | 32,462 Da |
| NCBI Full Name: | Syndecan-1 |
| NCBI Synonym Full Names: | syndecan 1 |
| NCBI Official Symbol: | SDC1 |
| NCBI Official Synonym Symbols: | SDC; CD138; SYND1; syndecan |
| NCBI Protein Information: | syndecan-1 |
| UniProt Protein Name: | Syndecan-1 |
| UniProt Synonym Protein Names: | CD_antigen: CD138 |
| Protein Family: | COMPASS component |
| UniProt Gene Name: | SDC1 |
| UniProt Entry Name: | SDC1_HUMAN |
 | Western blot - Syndecan-1/CD138 Rabbit mAb (CAB4174) |
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