Cell Biology Antibodies 17

Anti-Syndecan-1/CD138 Antibody (CAB4174)

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SKU:
CAB4174
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-Syndecan-1/CD138 Antibody
Antibody SKU:CAB4174
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Syndecan 1
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, HepG2, Mouse lung, Mouse kidney, Rat liver
Immunogen:A synthesized peptide derived from human Syndecan 1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6382
Uniprot:P18827
Cellular Location:Membrane, Secreted, Single-pass type I membrane protein
Calculated MW:35kDa
Observed MW:90-100KDa/180-230KDa
Synonyms:CD138, SDC, SYND1, syndecan
Background:The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
UniProt Protein Function:syndecan-1: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Belongs to the syndecan proteoglycan family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Extracellular matrix

Chromosomal Location of Human Ortholog: 2p24.1

Cellular Component: cell surface; cytoplasm; focal adhesion; Golgi lumen; integral to plasma membrane; lysosomal lumen; plasma membrane

Molecular Function:protein binding; protein C-terminus binding

Biological Process: cell migration; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; lipoprotein metabolic process; myoblast development; retinoid metabolic process; striated muscle cell development

NCBI Summary:The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
UniProt Code:P18827
NCBI GenInfo Identifier:229463011
NCBI Gene ID:6382
NCBI Accession:P18827.3
UniProt Secondary Accession:P18827,Q53QV0, Q546D3, Q96HB7, D6W523,
UniProt Related Accession:P18827,AAB21434,AAB23935
Molecular Weight:32,462 Da
NCBI Full Name:Syndecan-1
NCBI Synonym Full Names:syndecan 1
NCBI Official Symbol:SDC1  
NCBI Official Synonym Symbols:SDC; CD138; SYND1; syndecan  
NCBI Protein Information:syndecan-1
UniProt Protein Name:Syndecan-1
UniProt Synonym Protein Names:CD_antigen: CD138
Protein Family:COMPASS component
UniProt Gene Name:SDC1  
UniProt Entry Name:SDC1_HUMAN
Anti-Syndecan-1/CD138 Antibody (CAB4174)Western blot - Syndecan-1/CD138 Rabbit mAb (CAB4174)
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