Cell Biology Antibodies 12

Anti-Synaptopodin Antibody (CAB8484)

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SKU:
CAB8484
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-Synaptopodin Antibody
Antibody SKU:CAB8484
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human SYNPO (NP_001159680.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, HeLa, U-87MG, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human SYNPO (NP_001159680.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLGP HLPP PPLA PSEG RPTP CAFQ IPDG SYRC LALE AEES SGEE GLQG EVGP TDLE EDEG VSRS GDDS ACRV TQGT PQLP KALG IQPP SCSR EEQG ASQH DDRA SQDW DVVK AGQM MTAS PSPG PGPR VAQK PALG RSTS LTEK DLKE AKAR SQQI AAQL TTPP SSNS RGVQ LFNR RRQR VNEF TLES HGQR GQKP SQES LRVL PSSL PGHA PGLS LSST SLPE PGPP RHPS PQSP DRGV PGHS MEGY SEEA SLLR HLEK
Gene ID:11346
Uniprot:Q8N3V7
Cellular Location:Cell junction, Cell projection, Cytoplasm, Perikaryon, cytoskeleton, dendritic spine, postsynaptic cell membrane, postsynaptic density, synapse, tight junction
Calculated MW:73kDa/96kDa/99kDa
Observed MW:125kDa
Synonyms:SYNPO
Background:
UniProt Protein Function:SYNPO: an actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity.
UniProt Protein Details:

Protein type:Actin-binding; Cytoskeletal

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: actin cytoskeleton; dendritic spine

Molecular Function:actin binding; protein binding

NCBI Summary:Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997 [PubMed 9314539]).[supplied by OMIM, Mar 2008]
UniProt Code:Q8N3V7
NCBI GenInfo Identifier:48428650
NCBI Gene ID:11346
NCBI Accession:Q8N3V7.2
UniProt Secondary Accession:Q8N3V7,O15271, Q9UPX1, A5PKZ8, D3DQG8,
UniProt Related Accession:Q8N3V7
Molecular Weight:73,667 Da
NCBI Full Name:Synaptopodin
NCBI Synonym Full Names:synaptopodin
NCBI Official Symbol:SYNPO  
NCBI Protein Information:synaptopodin
UniProt Protein Name:Synaptopodin
Protein Family:Synaptopodin
UniProt Gene Name:SYNPO  
UniProt Entry Name:SYNPO_HUMAN
Anti-Synaptopodin Polyclonal Antibody (CAB8484)Western blot analysis of extracts of various cell lines, using SYNPO antibody (CAB8484) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-Synaptopodin Polyclonal Antibody (CAB8484)Immunohistochemistry of paraffin-embedded mouse kidney using SYNPO antibody (CAB8484) at dilution of 1:100 (40x lens).
Anti-Synaptopodin Polyclonal Antibody (CAB8484)Immunohistochemistry of paraffin-embedded human liver damage using SYNPO antibody (CAB8484) at dilution of 1:100 (40x lens).
Anti-Synaptopodin Polyclonal Antibody (CAB8484)Immunohistochemistry of paraffin-embedded rat kidney using SYNPO antibody (CAB8484) at dilution of 1:100 (40x lens).
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