Cell Biology Antibodies 7
Anti-SYN1 Antibody (CAB17362)
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- SKU:
- CAB17362
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SYN1 Antibody |
| Antibody SKU: | CAB17362 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SYN1. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | mouse heart, rat brain |
| Immunogen: | Recombinant protein of human SYN1. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6853 |
| Uniprot: | P17600 |
| Cellular Location: | Cell junction, Golgi apparatus, synapse |
| Calculated MW: | 70kDa/74kDa |
| Observed MW: | 74kDa |
| Synonyms: | SYN1, SYN1a, SYN1b, SYNI |
| Background: | This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | SYN1: neuronal phosphoprotein which associates with the cytoplasmic surface of synaptic vesicles and binds to the cytoskeleton. May function in the regulation of neurotransmitter release and of axonogenesis and synaptogenesis. Mutations may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Two differentially spiced isoforms have been reported. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: Xp11.23 Cellular Component: synaptic vesicle Molecular Function:ATP binding; protein binding; protein kinase binding; transporter activity Biological Process: regulation of neurotransmitter secretion; synaptic transmission Disease: Epilepsy, X-linked, With Variable Learning Disabilities And Behavior Disorders |
| NCBI Summary: | This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17600 |
| NCBI GenInfo Identifier: | 73920800 |
| NCBI Gene ID: | 6853 |
| NCBI Accession: | P17600.3 |
| UniProt Secondary Accession: | P17600,O75825, Q5H9A9, B1AJQ1, |
| UniProt Related Accession: | P17600 |
| Molecular Weight: | 70,033 Da |
| NCBI Full Name: | Synapsin-1 |
| NCBI Synonym Full Names: | synapsin I |
| NCBI Official Symbol: | SYN1 |
| NCBI Official Synonym Symbols: | SYNI; SYN1a; SYN1b |
| NCBI Protein Information: | synapsin-1 |
| UniProt Protein Name: | Synapsin-1 |
| UniProt Synonym Protein Names: | Brain protein 4.1; Synapsin I |
| Protein Family: | Synapsin |
| UniProt Gene Name: | SYN1 |
| UniProt Entry Name: | SYN1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SYN1 antibody (CAB17362) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3min. |
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