Cell Cycle Antibodies 2
Anti-SYCP3 Antibody (CAB9548)
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- SKU:
- CAB9548
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-SYCP3 Antibody |
| Antibody SKU: | CAB9548 |
| Antibody Size: | 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic Peptide of human SYCP3 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse ovary, Rat ovary |
| Immunogen: | A synthetic Peptide of human SYCP3 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 50511 |
| Uniprot: | Q8IZU3 |
| Cellular Location: | Chromosome, Nucleus |
| Calculated MW: | 27kDa |
| Observed MW: | 28kDa |
| Synonyms: | SYCP3, COR1, RPRGL4, SCP3, SPGF4 |
| Background: | This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. |
| UniProt Protein Function: | SYCP3: Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Defects in SYCP3 are the cause of spermatogenic failure type 4 (SPGF4). An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes. Belongs to the XLR/SYCP3 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 12q Cellular Component: chromosome; nucleus Molecular Function:DNA binding Biological Process: male meiosis I; cell division; spermatogenesis, exchange of chromosomal proteins Disease: Spermatogenic Failure 4 |
| NCBI Summary: | This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010] |
| UniProt Code: | Q8IZU3 |
| NCBI GenInfo Identifier: | 74728444 |
| NCBI Gene ID: | 50511 |
| NCBI Accession: | Q8IZU3.1 |
| UniProt Related Accession: | Q8IZU3 |
| Molecular Weight: | |
| NCBI Full Name: | Synaptonemal complex protein 3 |
| NCBI Synonym Full Names: | synaptonemal complex protein 3 |
| NCBI Official Symbol: | SYCP3 |
| NCBI Official Synonym Symbols: | COR1; SCP3; SPGF4; RPRGL4 |
| NCBI Protein Information: | synaptonemal complex protein 3 |
| UniProt Protein Name: | Synaptonemal complex protein 3 |
| Protein Family: | Synaptonemal complex protein |
| UniProt Gene Name: | SYCP3 |
| UniProt Entry Name: | SYCP3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SYCP3 antibody (CAB9548) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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