UniProt Protein Function: | SUV420H1: a protein methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Strongly down-regulated in breast cancer cells. Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily. Three alternatively-spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: nucleoplasm; nucleus Molecular Function:histone-lysine N-methyltransferase activity |
NCBI Summary: | This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
UniProt Code: | Q4FZB7 |
NCBI GenInfo Identifier: | 332278247 |
NCBI Gene ID: | 51111 |
NCBI Accession: | Q4FZB7.4 |
UniProt Secondary Accession: | Q4FZB7,Q3SX56, Q4V775, Q6P150, Q96E44, Q9BUL0, Q9H022 Q9H2K3, Q9NXV3, Q9Y393, B7WNX7, |
UniProt Related Accession: | Q4FZB7 |
Molecular Weight: | Calculated: 31kDa/44kDa/99kDaObserved: 92kDa |
NCBI Full Name: | Histone-lysine N-methyltransferase KMT5B |
NCBI Synonym Full Names: | lysine methyltransferase 5B |
NCBI Official Symbol: | KMT5B |
NCBI Official Synonym Symbols: | CGI85; CGI-85; SUV420H1 |
NCBI Protein Information: | histone-lysine N-methyltransferase KMT5B |
UniProt Protein Name: | Histone-lysine N-methyltransferase KMT5B |
UniProt Synonym Protein Names: | Lysine N-methyltransferase 5B; Lysine-specific methyltransferase 5B |
Protein Family: | Histone-lysine N-methyltransferase |
UniProt Gene Name: | KMT5B |