Cell Biology Antibodies 12
Anti-SUPV3L1 Antibody (CAB9951)
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- SKU:
- CAB9951
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SUPV3L1 Antibody |
| Antibody SKU: | CAB9951 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 577-786 of human SUPV3L1 (NP_003162.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:1000 - 1:4000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | K-562, Raji, Jurkat, SW620, Mouse heart, Mouse kidney, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 577-786 of human SUPV3L1 (NP_003162.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | APIN KKQP FVCS SLLQ FARQ YSRN EPLT FAWL RRYI KWPL LPPK NIKD LMDL EAVH DVLD LYLW LSYR FMDM FPDA SLIR DLQK ELDG IIQD GVHN ITKL IKMS ETHK LLNL EGFP SGSQ SRLS GTLK SQAR RTRG TKAL GSKA TEPP SPDA GELS LASR LVQQ GLLT PDML KQLE KEWM TQQT EHNK EKTE SGTH PKGT RRKK KEPD SD |
| Gene ID: | 6832 |
| Uniprot: | Q8IYB8 |
| Cellular Location: | Mitochondrion matrix, Nucleus, mitochondrion nucleoid |
| Calculated MW: | 87kDa |
| Observed MW: | 88kDa |
| Synonyms: | SUPV3L1, SUV3 |
| Background: |
| UniProt Protein Function: | SUPV3L1: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. Belongs to the helicase family. |
| UniProt Protein Details: | Protein type:Mitochondrial; EC 3.6.4.13; Helicase; DNA-binding; RNA-binding Chromosomal Location of Human Ortholog: 10q22.1 Cellular Component: mitochondrial matrix; mitochondrion; nucleus Molecular Function:ATP-dependent RNA helicase activity; DNA binding; DNA helicase activity; double-stranded RNA binding; helicase activity; protein binding; protein homodimerization activity; RNA binding Biological Process: DNA duplex unwinding; DNA recombination; negative regulation of apoptosis; positive regulation of cell growth; RNA catabolic process |
| UniProt Code: | Q8IYB8 |
| NCBI GenInfo Identifier: | 74759699 |
| NCBI Gene ID: | 6832 |
| NCBI Accession: | Q8IYB8.1 |
| UniProt Secondary Accession: | Q8IYB8,O43630, A8K301, |
| UniProt Related Accession: | Q8IYB8 |
| Molecular Weight: | 87,991 Da |
| NCBI Full Name: | ATP-dependent RNA helicase SUPV3L1, mitochondrial |
| NCBI Synonym Full Names: | Suv3 like RNA helicase |
| NCBI Official Symbol: | SUPV3L1 |
| NCBI Official Synonym Symbols: | SUV3 |
| NCBI Protein Information: | ATP-dependent RNA helicase SUPV3L1, mitochondrial |
| UniProt Protein Name: | ATP-dependent RNA helicase SUPV3L1, mitochondrial |
| UniProt Synonym Protein Names: | Suppressor of var1 3-like protein 1; SUV3-like protein 1 |
| Protein Family: | ATP-dependent RNA helicase |
| UniProt Gene Name: | SUPV3L1 |
| UniProt Entry Name: | SUV3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SUPV3L1 antibody (CAB9951) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunofluorescence analysis of NIH-3T3 cells using Anti-SUPV3L1 Polyclonal Antibody (CAB9951) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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