Immunology Antibodies 2

Anti-SUPT6H Antibody (CAB16434)

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SKU:
CAB16434
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-SUPT6H Antibody
Antibody SKU:CAB16434
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1500-1726 of human SUPT6H (NP_003161.2).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, Jurkat, HeLa, Mouse brain, Mouse heart, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1500-1726 of human SUPT6H (NP_003161.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IFPT VNGL FRWF KDHY QDPV PGIT PSSS SRTR TPAS INAT PANI NLAD LTRA VNAL PQNM TSQM FSAI AAVT GQGQ NPNA TPAQ WASS QYGY GGSG GGSS AYHV FPTP AQQP VATP LMTP SYSY TTPS QPIT TPQY HQLQ ASTT PQSA QAQP QPSS SSRQ RQQQ PKSN SHAA IDWG KMAE QWLQ EKEA ERRK QKQR LTPR PSPS PMIE STPM SIAG DATP LLDE MDR
Gene ID:6830
Uniprot:Q7KZ85
Cellular Location:Nucleus
Calculated MW:61kDa/84kDa/199kDa
Observed MW:260kDa
Synonyms:SUPT6H, SPT6, SPT6H, emb-5, SPT6 homolog
Background:
UniProt Protein Function:SPT6: promotes transcription elongation of many genes. A histone H3 chaperone that may alter chromatin structure during transcription. Binds RNA polymerase II (RNAPII) phosphorylated on Ser2 through its primitive SH2 domain, which appears to recognize phosphoserine rather than phosphotyrosine motifs. Associates with the nuclear mRNA export factor, THOC4.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator; RNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 17q11.2

Molecular Function:histone binding; protein binding; transcription factor activity

Biological Process: positive regulation of RNA elongation from RNA polymerase II promoter; regulation of isotype switching; regulation of mRNA processing; regulation of muscle cell differentiation

UniProt Code:Q7KZ85
NCBI GenInfo Identifier:51701986
NCBI Gene ID:6830
NCBI Accession:Q7KZ85.2
UniProt Secondary Accession:Q7KZ85,Q15737, Q6GMQ4, Q7KYW9, Q7LDK4, Q8N526, Q92775 Q96AH3, Q9BTH9, Q9BTI2, A7E2B4,
UniProt Related Accession:Q7KZ85
Molecular Weight:84,632 Da
NCBI Full Name:Transcription elongation factor SPT6
NCBI Synonym Full Names:SPT6 homolog, histone chaperone
NCBI Official Symbol:SUPT6H  
NCBI Official Synonym Symbols:SPT6; SPT6H; emb-5  
NCBI Protein Information:transcription elongation factor SPT6
UniProt Protein Name:Transcription elongation factor SPT6
UniProt Synonym Protein Names:Histone chaperone suppressor of Ty6; Tat-cotransactivator 2 protein; Tat-CT2 protein
UniProt Gene Name:SUPT6H  
UniProt Entry Name:SPT6H_HUMAN
Anti-SUPT6H Antibody (CAB16434)Western blot analysis of extracts of various cell lines, using SUPT6H antibody (CAB16434) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-SUPT6H Antibody (CAB16434)Immunofluorescence analysis of U-2 OS cells using SUPT6H antibody (CAB16434) at dilution of 1:100. Blue: DAPI for nuclear staining.
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