Anti-SUOX Antibody (CAB0733)
- SKU:
- CAB0733
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- SUOX
- Synonyms:
- sulfite oxidase
- Research Area:
- Metabolism
Description
| Product Name: | SUOX Rabbit mAb |
| Product Code: | CAB0733 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | SUOX, sulfite oxidase |
| Applications: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human SUOX. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat kidney |
| Immunogen: | A synthesized peptide derived from human SUOX. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6821 |
| Uniprot: | P51687 |
| Cellular Location: | Mitochondrion intermembrane space |
| Calculated MW: | 60kDa |
| Observed MW: | 60KDa |
| UniProt Protein Function: | SUOX: Defects in SUOX are the cause of isolated sulfite oxidase deficiency (ISOD); also known as sulfocysteinuria. ISOD is characterized by neurological abnormalities including multicystic leukoencephalopathy with brain atrophy. Patients often suffer from seizures. Often leads to death at an early age. |
| UniProt Protein Details: | Protein type:Mitochondrial; Energy Metabolism - sulfur; Oxidoreductase; EC 1.8.3.1 Chromosomal Location of Human Ortholog: 12q13.2 Cellular Component: mitochondrial matrix; mitochondrial intermembrane space Molecular Function:molybdopterin cofactor binding; electron carrier activity; molybdenum ion binding; heme binding; sulfite oxidase activity Biological Process: sulfur amino acid metabolic process; sulfur amino acid catabolic process Disease: Sulfocysteinuria |
| NCBI Summary: | Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51687 |
| NCBI GenInfo Identifier: | 152031695 |
| NCBI Gene ID: | 6821 |
| NCBI Accession: | P51687.2 |
| UniProt Related Accession: | P51687 |
| Molecular Weight: | 545 |
| NCBI Full Name: | Sulfite oxidase, mitochondrial |
| NCBI Synonym Full Names: | sulfite oxidase |
| NCBI Official Symbol: | SUOX |
| NCBI Protein Information: | sulfite oxidase, mitochondrial |
| UniProt Protein Name: | Sulfite oxidase, mitochondrial |
| Protein Family: | Sulfite oxidase |
| UniProt Gene Name: | SUOX |
| UniProt Entry Name: | SUOX_HUMAN |
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