Anti-SUN2 Antibody (CAB19782)
- SKU:
- CAB19782
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- UNC84B
- Research Area:
- Cell Biology
Description
| Product Name: | SUN2 Rabbit mAb |
| Product Code: | CAB19782 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | UNC84B |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human SUN2 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Jurkat |
| Immunogen: | A synthesized peptide derived from human SUN2 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 25777 |
| Uniprot: | Q9UH99 |
| Calculated MW: | 80kDa |
| Observed MW: | 80KDa |
| UniProt Protein Function: | SUN2: a nuclear transmembrane protein. Forms part of a membrane-spanning fibrillar complex that interconnects attached meiotic telomeres with cytoplasmic structures. Together with SUN1 connects the nuclear envelope with the centrosome. Interacts with RAB5A. Reportedly expressed in the endosome where it may play a role in endosome fusion and endocytosis. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Nuclear envelope Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: nuclear envelope; nuclear membrane Molecular Function:identical protein binding; lamin binding; microtubule binding; protein binding Biological Process: centrosome localization; mitotic spindle organization and biogenesis; nuclear membrane organization and biogenesis; nuclear migration; nuclear migration along microfilament; positive regulation of cell migration |
| NCBI Summary: | SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010] |
| UniProt Code: | Q9UH99 |
| NCBI GenInfo Identifier: | 29337242 |
| NCBI Gene ID: | 25777 |
| NCBI Accession: | Q9UH99.3 |
| UniProt Secondary Accession: | Q9UH99,O75156, Q2NKN8, Q2T9F7, Q504T5, Q6B4H1, Q7Z3E3 B0QY62, |
| UniProt Related Accession: | Q9UH99 |
| Molecular Weight: | 79,612 Da |
| NCBI Full Name: | SUN domain-containing protein 2 |
| NCBI Synonym Full Names: | Sad1 and UNC84 domain containing 2 |
| NCBI Official Symbol: | SUN2 |
| NCBI Official Synonym Symbols: | UNC84B |
| NCBI Protein Information: | SUN domain-containing protein 2 |
| UniProt Protein Name: | SUN domain-containing protein 2 |
| UniProt Synonym Protein Names: | Protein unc-84 homolog B; Rab5-interacting protein; Rab5IP; Sad1/unc-84 protein-like 2 |
| Protein Family: | SUN domain-containing protein |
| UniProt Gene Name: | SUN2 |
| UniProt Entry Name: | SUN2_HUMAN |
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