Developmental Biology

Anti-SUN1 Antibody (CAB16024)

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SKU:
CAB16024
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-SUN1 Antibody
Antibody SKU:CAB16024
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 29-278 of human SUN1 (NP_001165416.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 29-278 of human SUN1 (NP_001165416.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MYSP PQCV PENT GYTY ALSS SYSS DALD FETE HKLD PVFD SPRM SRRS LRLA TTAC TLGD GEAV GADS GTSS AVSL KNRA ARTT KQRR STNK SAFS INHV SRQV TSSG VSHG GTVS LQDA VTRR PPVL DESW IREQ TTVD HFWG LDDD GDLK GGNK AAIQ GNGD VGAA AATA HNGF SCSN CSML SERK DVLT AHPA APGP VSRV YSRD RNQK CKSQ SFKT QKKV CFPN LIFP FCKS QCLH YLSW RLKI IP
Gene ID:23353
Uniprot:O94901
Cellular Location:
Calculated MW:90kDa
Observed MW:90kDa
Synonyms:SUN1, UNC84A
Background:This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described.
UniProt Protein Function:SUN1: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non- coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cytoskeletal

Chromosomal Location of Human Ortholog: 7p22.3

Cellular Component: nuclear membrane; intracellular membrane-bound organelle; integral to nuclear inner membrane; nuclear envelope; acrosomal membrane

Molecular Function:protein binding; lamin binding

Biological Process: nuclear membrane organization and biogenesis

NCBI Summary:This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2010]
UniProt Code:O94901
NCBI GenInfo Identifier:195972890
NCBI Gene ID:23353
NCBI Accession:NP_001124437.1
UniProt Secondary Accession:O94901,Q96CZ7, Q9HA14, Q9UH98, A5PL20, B3KMV7, B4DZF7 B7WNY4, B7WP53, E9PDU4, E9PF23, F8WD13,
UniProt Related Accession:O94901
Molecular Weight:101,932 Da
NCBI Full Name:SUN domain-containing protein 1 isoform a
NCBI Synonym Full Names:Sad1 and UNC84 domain containing 1
NCBI Official Symbol:SUN1  
NCBI Official Synonym Symbols:UNC84A  
NCBI Protein Information:SUN domain-containing protein 1
UniProt Protein Name:SUN domain-containing protein 1
UniProt Synonym Protein Names:Protein unc-84 homolog A; Sad1/unc-84 protein-like 1
Protein Family:Secreted beta-glucosidase
UniProt Gene Name:SUN1  
UniProt Entry Name:SUN1_HUMAN
Anti-SUN1 Antibody (CAB16024)Western blot analysis of extracts of mouse testis, using SUN1 antibody (CAB16024) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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