Cell Biology Antibodies 13
Anti-SUMF2 Antibody (CAB17671)
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- SKU:
- CAB17671
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SUMF2 Antibody |
| Antibody SKU: | CAB17671 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 45-320 of human SUMF2 (NP_056226.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, A-549, HepG2, BxPC-3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 45-320 of human SUMF2 (NP_056226.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QATS MVQL QGGR FLMG TNSP DSRD GEGP VREA TVKP FAID IFPV TNKD FRDF VREK KYRT EAEM FGWS FVFE DFVS DELR NKAT QPMK SVLW WLPV EKAF WRQP AGPG SGIR ERLE HPVL HVSW NDAR AYCA WRGK RLPT EEEW EFAA RGGL KGQV YPWG NWFQ PNRT NLWQ GKFP KGDK AEDG FHGV SPVN AFPA QNNY GLYD LLGN VWEW TASP YQAA EQDM RVLR GASW IDTA DGSA NHRA RVTT RMGN TPDS ASDN LGFR CAAD AGRP PGEL |
| Gene ID: | 25870 |
| Uniprot: | Q8NBJ7 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 34kDa |
 | Western blot - SUMF2 Polyclonal Antibody (CAB17671) |
| Synonyms: | pFGE, SUMF2 |
| Background: | The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | SUMF2: Lacks formyl-glycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 7q11.1 Cellular Component: endoplasmic reticulum lumen Molecular Function:metal ion binding Biological Process: cellular protein metabolic process; post-translational protein modification |
| NCBI Summary: | The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8NBJ7 |
| NCBI GenInfo Identifier: | 226437577 |
| NCBI Gene ID: | 25870 |
| NCBI Accession: | NP_001139805.1 |
| UniProt Secondary Accession: | Q8NBJ7,Q14DW5, Q53ZE3, Q96BH2, Q9BRN3, Q9BWI1, Q9Y405 B4DU41, B4DWQ0, |
| UniProt Related Accession: | Q8NBJ7 |
| Molecular Weight: | 34,187 Da |
| NCBI Full Name: | sulfatase-modifying factor 2 isoform g |
| NCBI Synonym Full Names: | sulfatase modifying factor 2 |
| NCBI Official Symbol: | SUMF2 |
| NCBI Official Synonym Symbols: | pFGE |
| NCBI Protein Information: | sulfatase-modifying factor 2 |
| UniProt Protein Name: | Sulfatase-modifying factor 2 |
| UniProt Synonym Protein Names: | C-alpha-formylglycine-generating enzyme 2 |
| Protein Family: | Sulfatase-modifying factor |
| UniProt Gene Name: | SUMF2 |
| UniProt Entry Name: | SUMF2_HUMAN |
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