Metabolism Antibodies 2
Anti-SULT2A1 Antibody (CAB5489)
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- SKU:
- CAB5489
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-SULT2A1 Antibody |
| Antibody SKU: | CAB5489 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human SULT2A1 (NP_003158.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse skeletal muscle, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human SULT2A1 (NP_003158.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSDD FLWF EGIA FPTM GFRS ETLR KVRD EFVI RDED VIIL TYPK SGTN WLAE ILCL MHSK GDAK WIQS VPIW ERSP WVES EIGY TALS ETES PRLF SSHL PIQL FPKS FFSS KAKV IYLM RNPR DVLV SGYF FWKN MKFI KKPK S |
| Gene ID: | 6822 |
| Uniprot: | Q06520 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 33kDa |
| Observed MW: | 34kDa |
| Synonyms: | SULT2A1, DHEA-ST, DHEAS, HST, ST2, ST2A1, ST2A3, STD, hSTa |
| Background: | This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. |
| UniProt Protein Function: | SULT2A1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Belongs to the sulfotransferase 1 family. |
| UniProt Protein Details: | Protein type:EC 2.8.2.14; Transferase Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: cytosol Molecular Function:sulfotransferase activity; protein binding; bile-salt sulfotransferase activity Biological Process: steroid metabolic process; xenobiotic metabolic process; bile acid catabolic process; sulfation; digestion; cellular lipid metabolic process; 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| NCBI Summary: | This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q06520 |
| NCBI GenInfo Identifier: | 1711591 |
| NCBI Gene ID: | 6822 |
| NCBI Accession: | Q06520.3 |
| UniProt Related Accession: | Q06520 |
| Molecular Weight: | 285 |
| NCBI Full Name: | Bile salt sulfotransferase |
| NCBI Synonym Full Names: | sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 |
| NCBI Official Symbol: | SULT2A1 |
| NCBI Official Synonym Symbols: | HST; ST2; STD; hSTa; DHEAS; ST2A1; ST2A3; DHEA-ST |
| NCBI Protein Information: | bile salt sulfotransferase; bile-salt sulfotranasferase 2A1; alcohol/hydroxysteroid sulfotransferase |
| UniProt Protein Name: | Bile salt sulfotransferase |
| UniProt Synonym Protein Names: | Dehydroepiandrosterone sulfotransferase; DHEA-ST; Hydroxysteroid Sulfotransferase; HST; ST2; ST2A3; Sulfotransferase 2A1; ST2A1 |
| Protein Family: | Bile salt sulfotransferase |
| UniProt Gene Name: | SULT2A1 |
| UniProt Entry Name: | ST2A1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SULT2A1 antibody (CAB5489) at 1:2000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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