Metabolism Antibodies 1
Anti-SULT1A3 Antibody (CAB12357)
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- SKU:
- CAB12357
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-SULT1A3 Antibody |
| Antibody SKU: | CAB12357 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human SULT1A3 (NP_808220.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, LO2, 293T, HT-29, Mouse kidney, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human SULT1A3 (NP_808220.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MELI QDTS RPPL EYVK GVPL IKYF AEAL GPLQ SFQA RPDD LLIN TYPK SGTT WVSQ ILDM IYQG GDLE KCNR APIY VRVP FLEV NDPG EPSG LETL KDTP |
| Gene ID: | 6818 |
| Uniprot: | P0DMM9 |
| Cellular Location: | |
| Calculated MW: | 34kDa |
| Observed MW: | 34kDa |
| Synonyms: | SULT1A3, HAST, HAST3, M-PST, ST1A3, ST1A3/ST1A4, ST1A5, STM, TL-PST |
| Background: | Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. |
| UniProt Protein Function: | SULT1A3: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs. Belongs to the sulfotransferase 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.8.2.1; Energy Metabolism - sulfur; Transferase Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: cytosol Molecular Function:amine sulfotransferase activity; aryl sulfotransferase activity; protein binding; sulfate binding; sulfotransferase activity Biological Process: 3'-phosphoadenosine 5'-phosphosulfate metabolic process; dopamine catabolic process; dopamine receptor signaling pathway; ethanol catabolic process; flavonoid metabolic process; sulfation; xenobiotic metabolic process |
| NCBI Summary: | Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010] |
| UniProt Code: | P0DMM9 |
| NCBI GenInfo Identifier: | 678019022 |
| NCBI Gene ID: | 445329 |
| NCBI Accession: | P0DMM9.1 |
| UniProt Secondary Accession: | P0DMM9,O95603, P50224, Q1ET66, Q6ZWJ5, B4DNV0, |
| UniProt Related Accession: | P0DMN0 |
| Molecular Weight: | 34kDa |
| NCBI Full Name: | Sulfotransferase 1A3 |
| NCBI Synonym Full Names: | sulfotransferase family 1A member 4 |
| NCBI Official Symbol: | SULT1A4 |
| NCBI Official Synonym Symbols: | HAST3; M-PST; ST1A4; TL-PST; ST1A3/ST1A4 |
| NCBI Protein Information: | sulfotransferase 1A4 |
| UniProt Protein Name: | Sulfotransferase 1A3 |
| UniProt Synonym Protein Names: | Aryl sulfotransferase 1A3/1A4; Catecholamine-sulfating phenol sulfotransferase; HAST3; M-PST; Monoamine-sulfating phenol sulfotransferase; Placental estrogen sulfotransferase; Sulfotransferase 1A3/1A4; Sulfotransferase, monoamine-preferring; Thermolabile phenol sulfotransferase; TL-PST |
| Protein Family: | Sulfotransferase |
| UniProt Gene Name: | SULT1A3 |
 | Western blot analysis of extracts of various cell lines, using SULT1A3 antibody (CAB12357) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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