Metabolism Antibodies 3
Anti-SULT1A1 Antibody (CAB1599)
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- SKU:
- CAB1599
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-SULT1A1 Antibody |
| Antibody SKU: | CAB1599 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-295 of human SULT1A1 (NP_803565.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-295 of human SULT1A1 (NP_803565.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MELI QDTS RPPL EYVK GVPL IKYF AEAL GPLQ SFQA RPDD LLIS TYPK SGTT WVSQ ILDM IYQG GDLE KCHR APIF MRVP FLEF KAPG IPSG METL KDTP APRL LKTH LPLA LLPQ TLLD QKVK VVYV ARNA KDVA VSYY HFYH MAKV HPEP GTWD SFLE KFMV GEVS YGSW YQHV QEWW ELSR THPV LYLF YEDM KENP KREI QKIL EFVG RSLP EETV DFVV QHTS FKEM KKNP MTNY TTVP QEFM DHSI SPFM RKGM AGDW KTTF TVAQ NERF DADY AEKM AGCS LSFR SEL |
| Gene ID: | 6817 |
| Uniprot: | P50225 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 25kDa/34kDa |
| Observed MW: | 34kDa |
| Synonyms: | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 |
| Background: | Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. |
| UniProt Protein Function: | SULT1A1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. Belongs to the sulfotransferase 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.8.2.1; Energy Metabolism - sulfur; Transferase Chromosomal Location of Human Ortholog: 16p12.1 Cellular Component: cytosol Molecular Function:sulfotransferase activity; steroid sulfotransferase activity; flavonol 3-sulfotransferase activity; aryl sulfotransferase activity Biological Process: estrogen metabolic process; flavonoid metabolic process; xenobiotic metabolic process; sulfation; catecholamine metabolic process; amine metabolic process; 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| NCBI Summary: | Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P50225 |
| NCBI GenInfo Identifier: | 313104286 |
| NCBI Gene ID: | 6817 |
| NCBI Accession: | P50225.3 |
| UniProt Secondary Accession: | P50225,Q2NL71, Q86U58, Q92818, Q9BVU6, Q9UGG7, |
| UniProt Related Accession: | P50225 |
| Molecular Weight: | Calculated MW: 25kDa/34kDaObserve MW: 33kDa |
| NCBI Full Name: | Sulfotransferase 1A1 |
| NCBI Synonym Full Names: | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 |
| NCBI Official Symbol: | SULT1A1 |
| NCBI Official Synonym Symbols: | PST; STP; STP1; P-PST; ST1A1; ST1A3; TSPST1; HAST1/HAST2 |
| NCBI Protein Information: | sulfotransferase 1A1; ts-PST; P-PST 1; aryl sulfotransferase 1; thermostable phenol sulfotransferase1; phenol-sulfating phenol sulfotransferase 1 |
| UniProt Protein Name: | Sulfotransferase 1A1 |
| UniProt Synonym Protein Names: | Aryl sulfotransferase 1; HAST1/HAST2; Phenol sulfotransferase 1; Phenol-sulfating phenol sulfotransferase 1; P-PST 1; ST1A3; Thermostable phenol sulfotransferase; Ts-PST |
| Protein Family: | Sulfotransferase |
| UniProt Gene Name: | SULT1A1 |
| UniProt Entry Name: | ST1A1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SULT1A1 antibody (CAB1599) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse kidney using SULT1A1 antibody (CAB1599) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat brain using SULT1A1 antibody (CAB1599) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver damage using SULT1A1 antibody (CAB1599) at dilution of 1:100 (40x lens). |
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