Cell Biology Antibodies 12
Anti-SULF2 Antibody (CAB8803)
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- SKU:
- CAB8803
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SULF2 Antibody |
| Antibody SKU: | CAB8803 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 726-870 of human SULF2 (NP_061325.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 726-870 of human SULF2 (NP_061325.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TCFT HDNQ HWQT APFW TLGP FCAC TSAN NNTY WCMR TINE THNF LFCE FATG FLEY FDLN TDPY QLMN AVNT LDRD VLNQ LHVQ LMEL RSCK GYKQ CNPR TRNM DLGL KDGG SYEQ YRQF QRRK WPEM KRPS SKSL GQLW EGWE G |
| Gene ID: | 55959 |
| Uniprot: | Q8IWU5 |
| Cellular Location: | Cell surface, Endoplasmic reticulum, Golgi apparatus, Golgi stack |
| Calculated MW: | 100kDa |
| Observed MW: | 105kDa |
| Synonyms: | SULF2, HSULF-2 |
| Background: |
| UniProt Protein Function: | SULF2: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; EC 3.1.6.-; Hydrolase; Secreted Chromosomal Location of Human Ortholog: 20q13.12 Cellular Component: cell surface; endoplasmic reticulum; plasma membrane Molecular Function:arylsulfatase activity; N-acetylglucosamine-6-sulfatase activity Biological Process: cartilage development; chondrocyte development; embryonic skeletal development; esophagus smooth muscle contraction; glomerular basement membrane development; glomerular filtration; heparan sulfate proteoglycan metabolic process; kidney development; negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of Wnt receptor signaling pathway |
| NCBI Summary: | Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8IWU5 |
| NCBI GenInfo Identifier: | 33112446 |
| NCBI Gene ID: | 55959 |
| NCBI Accession: | Q8IWU5.1 |
| UniProt Secondary Accession: | Q8IWU5,Q5JYE1, Q6UX86, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3 E1P5U6, |
| UniProt Related Accession: | Q8IWU5 |
| Molecular Weight: | 100,156 Da |
| NCBI Full Name: | Extracellular sulfatase Sulf-2 |
| NCBI Synonym Full Names: | sulfatase 2 |
| NCBI Official Symbol: | SULF2 |
| NCBI Official Synonym Symbols: | HSULF-2 |
| NCBI Protein Information: | extracellular sulfatase Sulf-2 |
| UniProt Protein Name: | Extracellular sulfatase Sulf-2 |
| Protein Family: | Extracellular sulfatase |
| UniProt Gene Name: | SULF2 |
| UniProt Entry Name: | SULF2_HUMAN |
 | Western blot analysis of extracts of mouse brain, using SULF2 antibody (CAB8803) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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