Signal Transduction Antibodies 1

Anti-SUGT1 Antibody (CAB13908)

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SKU:
CAB13908
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-SUGT1 Antibody
Antibody SKU:CAB13908
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 159-333 of human SUGT1 (NP_006695.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Jurkat, A-431, 293T, Mouse lung, Mouse liver, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 159-333 of human SUGT1 (NP_006695.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NVQK NDVN VEFS EKEL SALV KLPS GEDY NLKL ELLH PIIP EQST FKVL STKI EIKL KKPE AVRW EKLE GQGD VPTP KQFV ADVK NLYP SSSP YTRN WDKL VGEI KEEE KNEK LEGD AALN RLFQ QIYS DGSD EVKR AMNK SFME SGGT VLST NWSD VGKR KVEI NPPD DMEW KKY
Gene ID:10910
Uniprot:Q9Y2Z0
Cellular Location:Cytoplasm, Nucleus
Calculated MW:37kDa/41kDa
Observed MW:38kDa/41kDa
Synonyms:SUGT1, SGT1
Background:This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes.
UniProt Protein Function:SUGT1: a protein involved in kinetochore function and required for the G1/S and G2/M transitions. A subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Two alternatively spliced isoforms have been reported.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system; Cell cycle regulation

Chromosomal Location of Human Ortholog: 13q14.3

Cellular Component: cytosol; kinetochore; protein complex; ubiquitin ligase complex

Molecular Function:protein binding

Biological Process: mitosis; regulation of protein stability

NCBI Summary:This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]
UniProt Code:Q9Y2Z0
NCBI GenInfo Identifier:62512186
NCBI Gene ID:10910
NCBI Accession:Q9Y2Z0.3
UniProt Secondary Accession:Q9Y2Z0,Q5JAK5, Q5TAM6, Q6VXY6, A2A303,
UniProt Related Accession:Q9Y2Z0
Molecular Weight:37,805 Da
NCBI Full Name:Protein SGT1 homolog
NCBI Synonym Full Names:SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
NCBI Official Symbol:SUGT1  
NCBI Official Synonym Symbols:SGT1  
NCBI Protein Information:protein SGT1 homolog
UniProt Protein Name:Protein SGT1 homolog
UniProt Synonym Protein Names:Protein 40-6-3
UniProt Gene Name:SUGT1  
UniProt Entry Name:SGT1_HUMAN
Anti-SUGT1 Antibody (CAB13908)Western blot analysis of extracts of various cell lines, using SUGT1 antibody (CAB13908) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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