Cell Biology Antibodies 8
Anti-SUGCT Antibody (CAB3499)
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- SKU:
- CAB3499
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SUGCT Antibody |
| Antibody SKU: | CAB3499 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human SUGCT (NP_001180240.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:200 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Mouse liver, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human SUGCT (NP_001180240.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPSE THAM LATL ARVA ALRR TCLF SGRG GGRG LWTG RPQS DMNN IKPL EGVK ILDL TRVL AGPF ATMN LGDL GAEV IKVE RPGA GDDT RTWG PPFV GTES TYYL SVNR NKKS IAVN IKDP KGVK IIKE LAAV CDVF VENY VPGK LSAM GLGY EDID EIAP HIIY CSIT GYGQ TGPI SQRA GYDA VASA VSGL MHIT GPEN GDPV RPGV AMTD LATG LYAY GAIM AGLI QKYK TGKG LFID CNLL SSQV AC |
| Gene ID: | 79783 |
| Uniprot: | Q9HAC7 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 43kDa/47kDa/48kDa/51kDa |
| Observed MW: | 48kDa |
| Synonyms: | SUGCT, C7orf10, DERP13, GA3, ORF19 |
| Background: | This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | SUGCT: Defects in C7orf10 are the cause of glutaric aciduria type 3 (GA3). GA3 is a metabolic disorder due to peroxisomal glutaryl-CoA oxidase deficiency and characterized by the excretion of abnormal quantities of glutaric acid but low 3- hydroxyglutaric acid. Belongs to the CaiB/BaiF CoA-transferase family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.8.3.13; Transferase Chromosomal Location of Human Ortholog: 7p14.1 Cellular Component: mitochondrion Molecular Function:succinate-hydroxymethylglutarate CoA-transferase activity Biological Process: metabolic process Disease: Glutaric Aciduria Iii |
| NCBI Summary: | This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010] |
| UniProt Code: | Q9HAC7 |
| NCBI GenInfo Identifier: | 71152390 |
| NCBI Gene ID: | 79783 |
| NCBI Accession: | Q9HAC7.2 |
| UniProt Secondary Accession: | Q9HAC7,Q4KMW4, Q4KMW8, Q4KMZ0, Q8TE00, Q8TEY1, A4D1W5 B4DR73, |
| UniProt Related Accession: | Q9HAC7 |
| Molecular Weight: | 445 |
| NCBI Full Name: | Succinate--hydroxymethylglutarate CoA-transferase |
| NCBI Synonym Full Names: | succinyl-CoA:glutarate-CoA transferase |
| NCBI Official Symbol: | SUGCT |
| NCBI Official Synonym Symbols: | ORF19; DERP13; C7orf10 |
| NCBI Protein Information: | succinate--hydroxymethylglutarate CoA-transferase; Russel-Silver syndrome candidate; dermal papilla-derived protein 13; succinylCoA:glutarate-CoA transferase |
| UniProt Protein Name: | Succinate--hydroxymethylglutarate CoA-transferase |
| UniProt Synonym Protein Names: | Dermal papilla-derived protein 13; SuccinylCoA:glutarate-CoA transferase |
| Protein Family: | Succinate--hydroxymethylglutarate CoA-transferase |
| UniProt Gene Name: | SUGCT |
| UniProt Entry Name: | SUCHY_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SUGCT antibody (CAB3499) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of U2OS cells using SUGCT antibody (CAB3499) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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