Cell Biology Antibodies 3
Anti-STYXL1 Antibody (CAB12850)
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- SKU:
- CAB12850
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-STYXL1 Antibody |
| Antibody SKU: | CAB12850 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human STYXL1 (NP_001304714.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A375, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human STYXL1 (NP_001304714.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPGL LLCE PTEL YNIL NQAT KLSR LTDP NYLC LLDV RSKW EYDE SHVI TALR VKKK NNEY LLPE SVDL ECVK YCVV YDNN SSTL EILL KDDD DDSD SDGD GKDL VPQA AIEY GRIL TRLT |
| Gene ID: | 51657 |
| Uniprot: | Q9Y6J8 |
| Cellular Location: | |
| Calculated MW: | 12kDa/24kDa/28kDa/35kDa/36kDa |
| Observed MW: | 36kDa |
| Synonyms: | STYXL1, DUSP24, MK-STYX, MKSTYX |
| Background: |
| UniProt Protein Function: | STYXL1: a pseudophosphatase of the dual specificity phosphatase sub-family of the protein tyrosine phosphatases. Contains a Ser residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphoprotein phosphatase. The binding pocket may be however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Interacts with G3BP-1, an RNA-binding protein with endoribonuclease activity that is recruited to stress granules (SGs) during stress. SGs are involved in mRNA sorting in the storing of untranslated mRNAs. STYXL1 inhibits G3BP-induced stress granule formation. Five isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 7q11.23 |
| UniProt Code: | Q9Y6J8 |
| NCBI GenInfo Identifier: | 29840801 |
| NCBI Gene ID: | 51657 |
| NCBI Accession: | Q9Y6J8.1 |
| UniProt Secondary Accession: | Q9Y6J8,Q9UBP1, Q9UK06, Q9UK07, Q9UKG2, Q9UKG3, |
| UniProt Related Accession: | Q9Y6J8 |
| Molecular Weight: | 36kDa |
| NCBI Full Name: | Serine/threonine/tyrosine-interacting-like protein 1 |
| NCBI Synonym Full Names: | serine/threonine/tyrosine interacting like 1 |
| NCBI Official Symbol: | STYXL1 |
| NCBI Official Synonym Symbols: | DUSP24; MKSTYX; MK-STYX |
| NCBI Protein Information: | serine/threonine/tyrosine-interacting-like protein 1 |
| UniProt Protein Name: | Serine/threonine/tyrosine-interacting-like protein 1 |
| UniProt Synonym Protein Names: | Dual specificity phosphatase inhibitor MK-STYX; Dual specificity protein phosphatase 24; Map kinase phosphatase-like protein MK-STYX |
| Protein Family: | Serine/threonine/tyrosine-interacting-like protein |
| UniProt Gene Name: | STYXL1 |
 | Western blot analysis of extracts of various cell lines, using STYXL1 antibody (CAB12850) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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