Signal Transduction Antibodies 1

Anti-STX8 Antibody (CAB10050)

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SKU:
CAB10050
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-STX8 Antibody
Antibody SKU:CAB10050
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human STX8 (NP_004844.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:SH-SY5Y, 293T, HepG2, SW480, Mouse lung, Mouse kidney, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human STX8 (NP_004844.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAPD PWFS TYDS TCQI AQEI AEKI QQRN QYER KGEK APKL TVTI RALL QNLK EKIA LLKD LLLR AVST HQIT QLEG DRRQ NLLD DLVT RERL LLAS FKNE GAEP DLIR SSLM SEEA KRGA PNPW LFEE PEET RGLG FDEI RQQQ QKII QEQD AGLD ALSS IISR QKQM GQEI GNEL DEQN EIID DLAN LVEN TDEK LRNE TRRV NMVD RKSA SCG
Gene ID:9482
Uniprot:Q9UNK0
Cellular Location:Membrane, Single-pass type IV membrane protein
Calculated MW:26kDa
Observed MW:27kDa
Synonyms:STX8, CARB
Background:The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:STX8: Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER. Belongs to the syntaxin family.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p12

Cellular Component: early endosome; endoplasmic reticulum; endosome; integral to plasma membrane; late endosome; perinuclear region of cytoplasm; recycling endosome; SNARE complex; trans-Golgi network; vesicle

Molecular Function:chloride channel inhibitor activity; protein binding; SNAP receptor activity; syntaxin binding

Biological Process: early endosome to late endosome transport; intracellular protein transport; transport; vesicle docking; vesicle fusion

NCBI Summary:The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
UniProt Code:Q9UNK0
NCBI GenInfo Identifier:9297054
NCBI Gene ID:9482
NCBI Accession:Q9UNK0.2
UniProt Secondary Accession:Q9UNK0,O60712, Q53XT8,
UniProt Related Accession:Q9UNK0
Molecular Weight:26,907 Da
NCBI Full Name:Syntaxin-8
NCBI Synonym Full Names:syntaxin 8
NCBI Official Symbol:STX8  
NCBI Official Synonym Symbols:CARB  
NCBI Protein Information:syntaxin-8
UniProt Protein Name:Syntaxin-8
Protein Family:Syntaxin
UniProt Gene Name:STX8  
UniProt Entry Name:STX8_HUMAN
Anti-STX8 Antibody (CAB10050)Western blot analysis of extracts of various cell lines, using STX8 antibody (CAB10050) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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