Cell Biology Antibodies 11
Anti-STX1A Antibody (CAB7931)
- SKU:
- CAB7931
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-STX1A Antibody |
| Antibody SKU: | CAB7931 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human STX1A |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide of human STX1A |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6804 |
| Uniprot: | Q16623 |
| Cellular Location: | Cell junction, Cell membrane, Cytoplasmic vesicle, Secreted, Single-pass type IV membrane protein, secretory vesicle, synapse, synaptic vesicle membrane, synaptosome |
| Calculated MW: | 28kDa/29kDa/33kDa |
| Observed MW: | 38kDa |
| Synonyms: | STX1A, HPC-1, P35-1, STX1, SYN1A, syntaxin-1A |
| Background: | This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | STX1A: a type IV membrane protein involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. Three splice variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Vesicle Cellular Component: actomyosin; cell junction; cytoplasmic vesicle; endomembrane system; integral to membrane; intracellular organelle; membrane; neuron projection; plasma membrane; protein complex; secretory granule; SNARE complex; synapse; synaptic vesicle; synaptic vesicle membrane; voltage-gated potassium channel complex Molecular Function:ATP-dependent protein binding; calcium channel inhibitor activity; calcium-dependent protein binding; chloride channel inhibitor activity; glycoprotein binding; kinase binding; myosin binding; myosin head/neck binding; protein binding; protein binding, bridging; protein domain specific binding; protein heterodimerization activity; protein N-terminus binding; SNAP receptor activity; SNARE binding Biological Process: calcium ion-dependent exocytosis; exocytosis; intracellular protein transport; neurotransmitter transport; positive regulation of calcium ion-dependent exocytosis; positive regulation of catecholamine secretion; positive regulation of exocytosis; positive regulation of neurotransmitter secretion; regulation of exocytosis; response to gravity; secretion by cell; synaptic vesicle fusion to presynaptic membrane; transport; vesicle docking; vesicle-mediated transport |
| NCBI Summary: | This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] |
| UniProt Code: | Q16623 |
| NCBI GenInfo Identifier: | 2501084 |
| NCBI Gene ID: | 6804 |
| NCBI Accession: | Q16623.1 |
| UniProt Secondary Accession: | Q16623,O35526, P32851, |
| UniProt Related Accession: | Q16623 |
| Molecular Weight: | 33,054 Da |
| NCBI Full Name: | Syntaxin-1A |
| NCBI Synonym Full Names: | syntaxin 1A |
| NCBI Official Symbol: | STX1A |
| NCBI Official Synonym Symbols: | STX1; HPC-1; P35-1; SYN1A |
| NCBI Protein Information: | syntaxin-1A |
| UniProt Protein Name: | Syntaxin-1A |
| UniProt Synonym Protein Names: | Neuron-specific antigen HPC-1 |
| Protein Family: | Syntaxin |
| UniProt Gene Name: | Stx1a |
| UniProt Entry Name: | STX1A_MOUSE |
 | Western blot analysis of extracts of various cell lines, using STX1A Rabbit pAb (CAB7931) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse kidney using STX1A antibody (CAB7931) (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat brain using STX1A antibody (CAB7931) (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using STX1A antibody (CAB7931) (40x lens). |
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