Cell Biology Antibodies 3

Anti-STRN3 Antibody (CAB12586)

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SKU:
CAB12586
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-STRN3 Antibody
Antibody SKU:CAB12586
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-460 of human STRN3 (NP_001077362.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-460 of human STRN3 (NP_001077362.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VRSL LGLS NSEP NGSV ETKN LEQI LNGG ESPK QKGQ EIKR SSGD VLET FNFL ENAD DSDE DEEN DMIE GIPE GKDK HRMN KHKI GNEG LAAD LTDD PDTE EALK EFDF LVTA EDGE GAGE ARSS GDGT EWDK DDLS PTAE VWDV DQGL ISKL KEQY KKER KGKK GVKR ANRT KLYD MIAD LGDD ELPH IPSG IINQ SRSA STRM TDHE GARA EEAE PITF PSGG GKSF IMGS DDVL LSVL GLGD LADL TVTN DADY SYDL P
Gene ID:29966
Uniprot:Q13033
Cellular Location:Cytoplasm, Membrane, Peripheral membrane protein
Calculated MW:77kDa/87kDa
Observed MW:110kDa
Synonyms:STRN3, PPP2R6B, S/G2NA, SG2NA
Background:
UniProt Protein Function:SG2NA: a protein of the WD-repeat striatin family. Mainly expressed within neurons and thought to act both as scaffolds and as Ca(2+)-dependent signalling proteins. May interact with protein phosphatase 2A. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Transcription factor; Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 14q13-q21

Cellular Component: nucleoplasm; Golgi apparatus; protein phosphatase type 2A complex; protein complex; cell soma; cytoplasm; dendrite; plasma membrane; nucleus

Molecular Function:calmodulin binding; protein binding; protein phosphatase 2A binding; protein complex binding; transcription factor activity

Biological Process: positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; response to estradiol stimulus; negative regulation of estrogen receptor signaling pathway

UniProt Code:Q13033
NCBI GenInfo Identifier:223634717
NCBI Gene ID:29966
NCBI Accession:Q13033.3
UniProt Secondary Accession:Q13033,Q9NRA5, A2RTX7, A6NHZ7,
UniProt Related Accession:Q13033
Molecular Weight:797
NCBI Full Name:Striatin-3
NCBI Synonym Full Names:striatin, calmodulin binding protein 3
NCBI Official Symbol:STRN3  
NCBI Official Synonym Symbols:SG2NA  
NCBI Protein Information:striatin-3; s/G2 antigen; nuclear autoantigen; cell cycle autoantigen SG2NA; cell cycle S/G2 nuclear autoantigen
UniProt Protein Name:Striatin-3
UniProt Synonym Protein Names:Cell cycle autoantigen SG2NA; S/G2 antigen
Protein Family:Striatin
UniProt Gene Name:STRN3  
UniProt Entry Name:STRN3_HUMAN
Anti-STRN3 Antibody (CAB12586)Western blot analysis of extracts of mouse brain, using STRN3 antibody (CAB12586) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-STRN3 Antibody (CAB12586)Immunofluorescence analysis of MCF7 cells using STRN3 antibody (CAB12586). Blue: DAPI for nuclear staining.
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