Epigenetics & Nuclear Signaling Antibodies 2

Anti-STRAP Antibody (CAB5964)

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SKU:
CAB5964
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-STRAP Antibody
Antibody SKU:CAB5964
Antibody Size:20uL, 50uL, 100uL
Application:WB IF IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human STRAP (NP_009109.3).
Application:WB IF IP
Recommended Dilution:WB 1:1000 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, HeLa, SW480, A-549, Mouse brain, Mouse lung, Mouse testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human STRAP (NP_009109.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAMR QTPL TCSG HTRP VVDL AFSG ITPY GYFL ISAC KDGK PMLR QGDT GDWI GTFL GHKG AVWG ATLN KDAT KAAT AAAD FTAK VWDA VSGD ELMT LAHK HIVK TVDF TQDS NYLL TGGQ DKLL RIYD LNKP EAEP KEIS GHTS GIKK ALWC SEDK QILS ADDK TVRL WDHA TMTE VKSL NFNM SVSS MEYI PEGE ILVI TYGR SIAF HSAV SLDP IKSF EAPA TINS ASLH PEKE FLVA GGED FKLY KYDY NSGE ELES YKGH FGPI HCVR FSPD GELY ASGS EDGT LRLW QTVV GKTY GLWK CVLP EEDS GELA KPKI GFPE TTEE ELEE IASE NSDC IFPS APDV KA
Gene ID:11171
Uniprot:Q9Y3F4
Cellular Location:Cytoplasm, Nucleus
Calculated MW:38kDa/39kDa
Observed MW:39kDa
Synonyms:STRAP, MAWD, PT-WD, UNRIP
Background:
UniProt Protein Function:STRAP: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Binds directly to GEMIN6 and GEMIN7. Associates with the complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1. Belongs to the WD repeat STRAP family.
UniProt Protein Details:

Protein type:RNA splicing; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12p12.3

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; SMN complex; nucleus; cytosol

Molecular Function:protein binding; receptor binding

Biological Process: spliceosomal snRNP biogenesis; transforming growth factor beta receptor signaling pathway; maintenance of gastrointestinal epithelium; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of epithelial cell proliferation

UniProt Code:Q9Y3F4
NCBI GenInfo Identifier:12643951
NCBI Gene ID:11171
NCBI Accession:Q9Y3F4.1
UniProt Secondary Accession:Q9Y3F4,Q5TZT4, Q9NTK0, Q9UQC8, B2R5S5, B4DNJ6,
UniProt Related Accession:Q9Y3F4
Molecular Weight:350
NCBI Full Name:Serine-threonine kinase receptor-associated protein
NCBI Synonym Full Names:serine/threonine kinase receptor associated protein
NCBI Official Symbol:STRAP  
NCBI Official Synonym Symbols:MAWD; PT-WD; UNRIP  
NCBI Protein Information:serine-threonine kinase receptor-associated protein; unr-interacting protein; WD-40 repeat protein PT-WD; MAP activator with WD repeats
UniProt Protein Name:Serine-threonine kinase receptor-associated protein
UniProt Synonym Protein Names:MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD
Protein Family:Serine-threonine kinase receptor-associated protein
UniProt Gene Name:STRAP  
UniProt Entry Name:STRAP_HUMAN
Anti-STRAP Antibody (CAB5964)Western blot analysis of extracts of various cell lines, using STRAP antibody (CAB5964) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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