Developmental Biology
Anti-STMN1 Antibody (CAB2176)
- SKU:
- CAB2176
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-STMN1 Antibody |
| Antibody SKU: | CAB2176 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-149 of human STMN1 (NP_981944.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW620, Mouse thymus, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-149 of human STMN1 (NP_981944.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MASS DIQV KELE KRAS GQAF ELIL SPRS KESV PEFP LSPP KKKD LSLE EIQK KLEA AEER RKSH EAEV LKQL AEKR EHEK EVLQ KAIE ENNN FSKM AEEK LTHK MEAN KENR EAQM AAKL ERLR EKDK HIEE VRKN KESK DPAD ETEA D |
| Gene ID: | 3925 |
| Uniprot: | P16949 |
| Cellular Location: | Cytoplasm, cytoskeleton |
| Calculated MW: | 17kDa/19kDa |
| Observed MW: | 16kDa |
| Synonyms: | STMN1, C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN, stathmin |
| Background: | This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | STMN1: a microtubule-associated protein involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Phosphorylation reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, nonleukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: cytoplasm; cytosol; intracellular; membrane; microtubule; neuron projection Molecular Function:protein binding; signal transducer activity; tubulin binding Biological Process: axonogenesis; brain development; microtubule depolymerization; mitotic spindle organization and biogenesis; negative regulation of microtubule polymerization; neurite development; positive regulation of cell motility; regulation of cytoskeleton organization and biogenesis; response to virus; signal transduction |
| NCBI Summary: | This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
| UniProt Code: | P16949 |
| NCBI GenInfo Identifier: | 134973 |
| NCBI Gene ID: | 3925 |
| NCBI Accession: | P16949.3 |
| UniProt Secondary Accession: | P16949,A2A2D1, B2R4E7, B7Z8N4, D3DPJ5, |
| UniProt Related Accession: | P16949 |
| Molecular Weight: | 19,824 Da |
| NCBI Full Name: | Stathmin |
| NCBI Synonym Full Names: | stathmin 1 |
| NCBI Official Symbol: | STMN1 |
| NCBI Official Synonym Symbols: | Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215 |
| NCBI Protein Information: | stathmin |
| UniProt Protein Name: | Stathmin |
| UniProt Synonym Protein Names: | Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17 |
| Protein Family: | Stathmin |
| UniProt Gene Name: | STMN1 |
| UniProt Entry Name: | STMN1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using STMN1 antibody (CAB2176) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat brain using STMN1 Rabbit pAb (CAB2176) at dilution of 1:100 (40x lens). |
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