Anti-STK39 Antibody (CAB2275)

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SKU:
CAB2275
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
DCHT
Synonyms:
PASK
Synonyms:
SPAK
Research Area:
Cell Biology

Description

Product Name:STK39 Rabbit mAb
Product Code:CAB2275
Size:20uL, 50uL, 100uL
Synonyms:DCHT, PASK, SPAK
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human STK39
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, SH-SY5Y, Rat testis, Mouse testis
Immunogen:A synthesized peptide derived from human STK39
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:27347
Uniprot:Q9UEW8
Cellular Location:Cytoplasm, Nucleus
Calculated MW:68kDa
Observed MW:71kDa
UniProt Protein Function:STLK3: May act as a mediator of stress-activated signals. The phosphorylated form forms a complex with WNK2. Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
UniProt Protein Details:

Protein type:Kinase, protein; EC 2.7.11.1; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; FRAY subfamily

Chromosomal Location of Human Ortholog: 2q24.3

Cellular Component: apical plasma membrane; basolateral plasma membrane; cytoplasm; cytoskeleton; nucleus

Molecular Function:ATP binding; protein binding; protein kinase binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: activation of protein kinase activity; negative regulation of protein amino acid phosphorylation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of potassium ion transport; protein amino acid phosphorylation; regulation of apoptosis; regulation of blood pressure; regulation of inflammatory response; regulation of mitotic cell cycle; response to stress; stress-activated protein kinase signaling pathway

NCBI Summary:This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UEW8
NCBI GenInfo Identifier:317373508
NCBI Gene ID:27347
NCBI Accession:Q9UEW8.3
UniProt Secondary Accession:Q9UEW8,O14774, Q53S90, Q53SL7, Q53SS1, Q9UER4, X5D9C8
UniProt Related Accession:Q9UEW8
Molecular Weight:57,937 Da
NCBI Full Name:STE20/SPS1-related proline-alanine-rich protein kinase
NCBI Synonym Full Names:serine/threonine kinase 39
NCBI Official Symbol:STK39  
NCBI Official Synonym Symbols:DCHT; PASK; SPAK  
NCBI Protein Information:STE20/SPS1-related proline-alanine-rich protein kinase
UniProt Protein Name:STE20/SPS1-related proline-alanine-rich protein kinase
UniProt Synonym Protein Names:DCHT; Serine/threonine-protein kinase 39
Protein Family:STE20/SPS1-related proline-alanine-rich protein kinase
UniProt Gene Name:STK39  
UniProt Entry Name:STK39_HUMAN
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