Anti-STK36 Antibody (CAB10974)

(No reviews yet) Write a Review
SKU:
CAB10974
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
STK36
Synonyms:
FU

Description

Product Name:STK36 Rabbit pAb
Product Code:CAB10974
Size:50uL, 100uL
Synonyms:STK36, FU
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 250-450 of human STK36 (NP_056505.2).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse brain, Mouse testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 250-450 of human STK36 (NP_056505.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:27148
Uniprot:Q9NRP7
Cellular Location:Cytoplasm, Nucleus
Calculated MW:141kDa/143kDa
Observed MW:144kDa
UniProt Protein Function:Fused: a serine/threonine protein kinase of the ULK family. Plays a role in Hedgehog (Hh) signaling. Interacts with Smoothened (Smo), the receptor for Hedgehog (Hh). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of Fused to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); ULK family

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function:ATP binding; magnesium ion binding; protein binding; protein serine/threonine kinase activity; transcription factor binding

Biological Process: activation of hh target transcription factor; positive regulation of smoothened signaling pathway; post-embryonic development; protein amino acid phosphorylation; regulation of transcription factor activity

NCBI Summary:This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
UniProt Code:Q9NRP7
NCBI GenInfo Identifier:90101761
NCBI Gene ID:27148
NCBI Accession:Q9NRP7.2
UniProt Secondary Accession:Q9NRP7,Q8TC32, Q9H9N9, Q9UF35, Q9ULE2, B7WPM3,
UniProt Related Accession:Q9NRP7
Molecular Weight:144kDa
NCBI Full Name:Serine/threonine-protein kinase 36
NCBI Synonym Full Names:serine/threonine kinase 36
NCBI Official Symbol:STK36  
NCBI Official Synonym Symbols:FU  
NCBI Protein Information:serine/threonine-protein kinase 36
UniProt Protein Name:Serine/threonine-protein kinase 36
UniProt Synonym Protein Names:Fused homolog
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:STK36  
View AllClose

0 Reviews

View AllClose

Related Products