Anti-STIP1 Antibody (CAB0036)
- SKU:
- CAB0036
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HEL-S-94n
- Synonyms:
- HOP
- Synonyms:
- IEF-SSP-3521
- Synonyms:
- P60
- Synonyms:
- STI1
- Synonyms:
- STI1L
- Research Area:
- Cell Biology
Description
| Product Name: | STIP1 Rabbit mAb |
| Product Code: | CAB0036 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human STIP1 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, NIH/3T3, Mouse testis, Mouse brain, Rat brain, Rat thymus |
| Immunogen: | A synthesized peptide derived from human STIP1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10963 |
| Uniprot: | P31948 |
| Calculated MW: | 63kDa |
| Observed MW: | 68kDa |
| UniProt Protein Function: | STI1: a protein that is apparently involved in the response to stress. Specifically interacts with the C-terminal tails of Hsp70 and Hsp90 via TPR1 and TPR2A domains. Deletion of STI1 reduces the activity of the glucocorticoid receptor, a Hsp90 target protein. Phosphorylated in vitro by p90RSK and casein kinase II. |
| UniProt Protein Details: | Protein type:Chaperone Chromosomal Location of Human Ortholog: 11q13 Cellular Component: Golgi apparatus; nucleus Molecular Function:protein binding Biological Process: response to stress |
| NCBI Summary: | STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009] |
| UniProt Code: | P31948 |
| NCBI GenInfo Identifier: | 400042 |
| NCBI Gene ID: | 10963 |
| NCBI Accession: | P31948.1 |
| UniProt Secondary Accession: | P31948,Q3ZCU9, Q5TZU9, B4DM70, F5H0T1, G3XAD8, |
| UniProt Related Accession: | P31948 |
| Molecular Weight: | 543 |
| NCBI Full Name: | Stress-induced-phosphoprotein 1 |
| NCBI Synonym Full Names: | stress-induced phosphoprotein 1 |
| NCBI Official Symbol: | STIP1 |
| NCBI Official Synonym Symbols: | HOP; P60; STI1; STI1L; HEL-S-94n; IEF-SSP-3521 |
| NCBI Protein Information: | stress-induced-phosphoprotein 1; NY-REN-11 antigen; Hsp70/Hsp90-organizing protein; hsc70/Hsp90-organizing protein; renal carcinoma antigen NY-REN-11; transformation-sensitive protein IEF SSP 3521; epididymis secretory sperm binding protein Li 94n |
| UniProt Protein Name: | Stress-induced-phosphoprotein 1 |
| UniProt Synonym Protein Names: | Hsc70/Hsp90-organizing protein; Hop; Renal carcinoma antigen NY-REN-11; Transformation-sensitive protein IEF SSP 3521 |
| Protein Family: | STIP1 homology and U box-containing protein |
| UniProt Gene Name: | STIP1 |
| UniProt Entry Name: | STIP1_HUMAN |
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