Cell Biology Antibodies 13

Anti-STIM2 Antibody (CAB17743)

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SKU:
CAB17743
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-STIM2 Antibody
Antibody SKU:CAB17743
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human STIM2 (NP_001162588).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human STIM2 (NP_001162588).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CFTE EDRF SLEA LQTI HKQM DDDK DGGI EVEE SDEF IRED MKYK DATN KHSH LHRE DKHI TIED LWKR WKTS EVHN WTLE DTLQ WLIE FVEL PQYE KNFR DNNV KGTT LPRI AVHE PSFM I
Gene ID:57620
Uniprot:Q9P246
Cellular Location:
Calculated MW:68kDa/83kDa/93kDa
Observed MW:110kDa
Anti-STIM2 Antibody (CAB17743)Western blot - STIM2 Rabbit pAb (CAB17743)
Synonyms:STIM2
Background:This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009]
UniProt Protein Function:Plays a role in mediating store-operated Ca2+ entry (SOCE), a Ca2+ influx following depletion of intracellular Ca2+ stores. Functions as a highly sensitive Ca2+ sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca2+-influx. Regulates basal cytosolic and endoplasmic reticulum Ca2+ concentrations. Upon mild variations of the endoplasmic reticulum Ca2+ concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca2+ release-activated Ca2+ (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca2+ influx.
NCBI Summary:This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009]
UniProt Code:Q9P246
NCBI GenInfo Identifier:17369338
NCBI Gene ID:57620
NCBI Accession:Q9P246.2
UniProt Secondary Accession:Q9P246,Q96BF1, Q9BQH2, Q9H8R1, A6H8L7, B7ZVY0,
UniProt Related Accession:Q9P246
Molecular Weight:68,026 Da
NCBI Full Name:Stromal interaction molecule 2
NCBI Synonym Full Names:stromal interaction molecule 2
NCBI Official Symbol:STIM2  
NCBI Protein Information:stromal interaction molecule 2
UniProt Protein Name:Stromal interaction molecule 2
Protein Family:Stromal interaction molecule
UniProt Gene Name:STIM2  
UniProt Entry Name:STIM2_HUMAN
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