Cell Biology Antibodies 15

Anti-STEAP4 Antibody (CAB17767)

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SKU:
CAB17767
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-STEAP4 Antibody
Antibody SKU:CAB17767
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human STEAP4 (NP_001192245).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Rat liver, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human STEAP4 (NP_001192245).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEKT CIDA LPLT MNSS EKQE TVCI FGTG DFGR SLGL KMLQ CGYS VVFG SRNP QKTT LLPS GAEV LSYS EAAK KSGI IIIA IHRE HYDF LTEL TEVL NGKI
Gene ID:79689
Uniprot:Q687X5
Cellular Location:
Calculated MW:31kDa/51kDa
Observed MW:52kDa
Anti-STEAP4 Antibody (CAB17767)Western blot - STEAP4 Polyclonal Antibody (CAB17767)
Synonyms:STAMP2, SchLAH, TIARP, TNFAIP9, STEAP4
Background:The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]
UniProt Protein Function:STEAP4: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation. Belongs to the STEAP family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; EC 1.16.1.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 7q21.12

Cellular Component: Golgi membrane; integral to membrane; plasma membrane; endosome

Molecular Function:metal ion binding; cupric reductase activity

Biological Process: fat cell differentiation; iron ion homeostasis; copper ion import

NCBI Summary:The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]
UniProt Code:Q687X5
NCBI GenInfo Identifier:74748242
NCBI Gene ID:79689
NCBI Accession:Q687X5.1
UniProt Secondary Accession:Q687X5,Q658Q9, Q687X4, Q8WWB0, Q9H5R1,
UniProt Related Accession:Q687X5
Molecular Weight:52kDa
NCBI Full Name:Metalloreductase STEAP4
NCBI Synonym Full Names:STEAP family member 4
NCBI Official Symbol:STEAP4  
NCBI Official Synonym Symbols:TIARP; STAMP2; TNFAIP9  
NCBI Protein Information:metalloreductase STEAP4; six transmembrane prostate protein 2; sixTransMembrane protein of prostate 2; tumor necrosis factor, alpha-induced protein 9; six-transmembrane epithelial antigen of prostate 4; tumor necrosis-alpha-induced adipose-related protein
UniProt Protein Name:Metalloreductase STEAP4
UniProt Synonym Protein Names:Six-transmembrane epithelial antigen of prostate 4; SixTransMembrane protein of prostate 2; Tumor necrosis factor, alpha-induced protein 9
Protein Family:Metalloreductase
UniProt Gene Name:STEAP4  
UniProt Entry Name:STEA4_HUMAN
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