Cell Biology Antibodies 7
Anti-STC1 Antibody (CAB16976)
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- SKU:
- CAB16976
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-STC1 Antibody |
| Antibody SKU: | CAB16976 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-247 of human STC1 (NP_003146.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:1000 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | mouse kidney, rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-247 of human STC1 (NP_003146.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | THEA EQND SVSP RKSR VAAQ NSAE VVRC LNSA LQVG CGAF ACLE NSTC DTDG MYDI CKSF LYSA AKFD TQGK AFVK ESLK CIAN GVTS KVFL AIRR CSTF QRMI AEVQ EECY SKLN VCSI AKRN PEAI TEVV QLPN HFSN RYYN RLVR SLLE CDED TVST IRDS LMEK IGPN MASL FHIL QTDH CAQT HPRA DFNR RRTN EPQK LKVL LRNL RGEE DSPS HIKR TSHE SA |
| Gene ID: | 6781 |
| Uniprot: | P52823 |
| Cellular Location: | |
| Calculated MW: | 20kDa/27kDa |
| Observed MW: | 27kDa |
| Synonyms: | STC1, STC |
| Background: | This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. |
| UniProt Protein Function: | STC1: Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia. Belongs to the stanniocalcin family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 8p21.2 Cellular Component: extracellular space; cytoplasm; apical plasma membrane; nucleus Molecular Function:hormone activity Biological Process: cellular calcium ion homeostasis; negative regulation of calcium ion transport; ossification; response to vitamin D; endothelial cell morphogenesis; decidualization; negative regulation of cell migration; embryo implantation |
| NCBI Summary: | This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P52823 |
| NCBI GenInfo Identifier: | 1706175 |
| NCBI Gene ID: | 6781 |
| NCBI Accession: | P52823.1 |
| UniProt Secondary Accession: | P52823,Q71UE5, |
| UniProt Related Accession: | P52823 |
| Molecular Weight: | |
| NCBI Full Name: | Stanniocalcin-1 |
| NCBI Synonym Full Names: | stanniocalcin 1 |
| NCBI Official Symbol: | STC1 |
| NCBI Official Synonym Symbols: | STC |
| NCBI Protein Information: | stanniocalcin-1 |
| UniProt Protein Name: | Stanniocalcin-1 |
| Protein Family: | Stanniocalcin |
| UniProt Gene Name: | STC1 |
| UniProt Entry Name: | STC1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using STC1 antibody (CAB16976) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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