Signal Transduction Antibodies 1

Anti-STAU2 Antibody (CAB14117)

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SKU:
CAB14117
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-STAU2 Antibody
Antibody SKU:CAB14117
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 300-400 of human STAU2 (NP_001157852.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, A-549, Mouse heart, Rat heart
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 300-400 of human STAU2 (NP_001157852.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PEYG QGMN PISR LAQI QQAK KEKE PDYV LLSE RGMP RRRE FVMQ VKVG NEVA TGTG PNKK IAKK NAAE AMLL QLGY KAST NLQD QLEK TGEN KGWS GPKP G
Gene ID:27067
Uniprot:Q9NUL3
Cellular Location:Cytoplasm, Endoplasmic reticulum, Nucleus, nucleolus
Calculated MW:11kDa/34kDa/43kDa/52kDa/55kDa/59kDa/62kDa
Observed MW:49kDa
Synonyms:STAU2, 39K2, 39K3
Background:Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:STAU2: RNA-binding protein required for the microtubule- dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nuclear export; RNA-binding; Nucleolus

Chromosomal Location of Human Ortholog: 8q21.11

Cellular Component: microtubule; membrane; endoplasmic reticulum; nucleolus

Molecular Function:protein binding; double-stranded RNA binding

Biological Process: transport

UniProt Code:Q9NUL3
NCBI GenInfo Identifier:73919458
NCBI Gene ID:
NCBI Accession:Q9NUL3.1
Molecular Weight:~ 52kDa
NCBI Full Name:Double-stranded RNA-binding protein Staufen homolog 2
UniProt Protein Name:Double-stranded RNA-binding protein Staufen homolog 2
Protein Family:Double-stranded RNA-binding protein
UniProt Gene Name:STAU2  
UniProt Entry Name:STAU2_HUMAN
Anti-STAU2 Antibody (CAB14117)Western blot analysis of extracts of various cell lines, using STAU2 antibody (CAB14117) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-STAU2 Antibody (CAB14117)Immunofluorescence analysis of U2OS cells using STAU2 antibody (CAB14117) at dilution of 1:100. Blue: DAPI for nuclear staining.
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