Developmental Biology

Anti-Stathmin 1 Antibody (CAB4379)

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SKU:
CAB4379
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
C1orf215
Synonyms:
LAP18
Synonyms:
Lag
Synonyms:
OP18
Synonyms:
PP17
Synonyms:
PP19
Synonyms:
PR22
Synonyms:
SMN
Research Area:
Developmental Biology

Description

Product Name:Stathmin 1 Rabbit mAb
Product Code:CAB4379
Size:20uL, 50uL, 100uL
Synonyms:C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Stathmin 1
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Mouse testis, Mouse brain, Mouse thymus, Rat brain
Immunogen:A synthesized peptide derived from human Stathmin 1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3925
Uniprot:P16949
Cellular Location:Cytoplasm, cytoskeleton
Calculated MW:18kDa
Observed MW:18KDa
UniProt Protein Function:STMN1: a microtubule-associated protein involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Phosphorylation reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, nonleukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: cytoplasm; cytosol; intracellular; membrane; microtubule; neuron projection

Molecular Function:protein binding; signal transducer activity; tubulin binding

Biological Process: axonogenesis; brain development; microtubule depolymerization; mitotic spindle organization and biogenesis; negative regulation of microtubule polymerization; neurite development; positive regulation of cell motility; regulation of cytoskeleton organization and biogenesis; response to virus; signal transduction

NCBI Summary:This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
UniProt Code:P16949
NCBI GenInfo Identifier:134973
NCBI Gene ID:3925
NCBI Accession:P16949.3
UniProt Secondary Accession:P16949,A2A2D1, B2R4E7, B7Z8N4, D3DPJ5,
UniProt Related Accession:P16949
Molecular Weight:19,824 Da
NCBI Full Name:Stathmin
NCBI Synonym Full Names:stathmin 1
NCBI Official Symbol:STMN1  
NCBI Official Synonym Symbols:Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215  
NCBI Protein Information:stathmin
UniProt Protein Name:Stathmin
UniProt Synonym Protein Names:Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17
Protein Family:Stathmin
UniProt Gene Name:STMN1  
UniProt Entry Name:STMN1_HUMAN
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