Epigenetics & Nuclear Signaling Antibodies 1

Anti-STAT6 Antibody (CAB0755)

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SKU:
CAB0755
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-STAT6 Antibody
Antibody SKU:CAB0755
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human STAT6 (NP_001171550.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, Jurkat, HeLa, Mouse spleen, Mouse lung, Mouse liver, Rat spleen, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human STAT6 (NP_001171550.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSLW GLVS KMPP EKVQ RLYV DFPQ HLRH LLGD WLES QPWE FLVG SDAF CCNL ASAL LSDT VQHL QASV GEQG EGST ILQH ISTL ESIY QRDP LKLV ATFR QILQ GEKK AVME QFRH LPMP FHWK QEEL KFKT GLRR LQHR VGEI HLLR EALQ KGAE AGQV SLHS LIET PANG TGPS EALA
Gene ID:6778
Uniprot:P42226
Cellular Location:Cytoplasm, Nucleus
Calculated MW:74kDa/81kDa/94kDa
Observed MW:110kDa
Synonyms:D12S1644, IL-4-STAT, STAT6B, STAT6C, STAT6
Background:The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:STAT6: transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: cytoplasm; cytosol; lipid raft; nuclear chromatin; nucleoplasm

Molecular Function:identical protein binding; protein binding; protein phosphatase binding; signal transducer activity; transcription factor activity

Biological Process: mammary gland epithelial cell proliferation; negative regulation of T-helper 2 type immune response; negative regulation of transcription from RNA polymerase II promoter; positive regulation of interferon type I production; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; signal transduction; T-helper 1 cell lineage commitment; transcription, DNA-dependent

NCBI Summary:The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Code:P42226
NCBI GenInfo Identifier:1174459
NCBI Gene ID:6778
NCBI Accession:P42226.1
UniProt Secondary Accession:P42226,Q5FBW5, Q71UP4, A8K316, B7ZA27, F5GXI9,
UniProt Related Accession:P42226
Molecular Weight:
NCBI Full Name:Signal transducer and activator of transcription 6
NCBI Synonym Full Names:signal transducer and activator of transcription 6
NCBI Official Symbol:STAT6  
NCBI Official Synonym Symbols:STAT6B; STAT6C; D12S1644; IL-4-STAT  
NCBI Protein Information:signal transducer and activator of transcription 6
UniProt Protein Name:Signal transducer and activator of transcription 6
UniProt Synonym Protein Names:IL-4 Stat
Protein Family:Signal transducer and transcription activator
UniProt Gene Name:STAT6  
UniProt Entry Name:STAT6_HUMAN
Anti-STAT6 Antibody (CAB0755)Western blot analysis of extracts of various cell lines, using STAT6 antibody (CAB0755) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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