Epigenetics & Nuclear Signaling Antibodies 3
Anti-STAT4 Antibody (CAB2638)
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- SKU:
- CAB2638
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-STAT4 Antibody |
| Antibody SKU: | CAB2638 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 600-700 of human STAT4 (NP_001230764.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse testis, Rat testis |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 600-700 of human STAT4 (NP_001230764.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SESH LGGI TFTW VDHS ESGE VRFH SVEP YNKG RLSA LPFA DILR DYKV IMAE NIPE NPLK YLYP DIPK DKAF GKHY SSQP CEVS RPTE RGDK GYVP SVFI P |
| Gene ID: | 6775 |
| Uniprot: | Q14765 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 85kDa |
| Observed MW: | 93kDa |
| Synonyms: | STAT4, SLEB11 |
| Background: | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. |
| UniProt Protein Function: | STAT4: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 2q32.2-q32.3 Cellular Component: nucleoplasm; cytoplasm Molecular Function:protein binding; signal transducer activity; sequence-specific DNA binding; transcription factor activity Biological Process: cell proliferation; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; JAK-STAT cascade; protein amino acid phosphorylation Disease: Systemic Lupus Erythematosus, Susceptibility To, 11 |
| NCBI Summary: | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q14765 |
| NCBI GenInfo Identifier: | 6226158 |
| NCBI Gene ID: | 6775 |
| NCBI Accession: | Q14765.1 |
| UniProt Secondary Accession: | Q14765,Q96NZ6, |
| UniProt Related Accession: | Q14765 |
| Molecular Weight: | 85,941 Da |
| NCBI Full Name: | Signal transducer and activator of transcription 4 |
| NCBI Synonym Full Names: | signal transducer and activator of transcription 4 |
| NCBI Official Symbol: | STAT4 |
| NCBI Official Synonym Symbols: | SLEB11 |
| NCBI Protein Information: | signal transducer and activator of transcription 4 |
| UniProt Protein Name: | Signal transducer and activator of transcription 4 |
| Protein Family: | Protein slender lobes |
| UniProt Gene Name: | STAT4 |
| UniProt Entry Name: | STAT4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using STAT4 antibody (CAB2638) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded Human colon using STAT4 Rabbit pAb (CAB2638) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Mouse spleen using STAT4 Rabbit pAb (CAB2638) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Rat testis using STAT4 Rabbit pAb (CAB2638) at dilution of 1:100 (40x lens). |
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