Cell Biology Antibodies 6

Anti-STARD4 Antibody (CAB15955)

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SKU:
CAB15955
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-STARD4 Antibody
Antibody SKU:CAB15955
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human STARD4 (NP_001294986.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse kidney, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human STARD4 (NP_001294986.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEGL SDVA SFAT KLKN TLIQ YHSI EEDK WRVA KKTK DVTV WRKP SEEF NGYL YKAQ GVID DLVY SIID HIRP GPCR LDWD SLMT SLDI LENF EENC CVMR
Gene ID:134429
Uniprot:Q96DR4
Cellular Location:
Calculated MW:18kDa/23kDa
Observed MW:24kDa
Synonyms:STARD4
Background:Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]).
UniProt Protein Function:STARD4: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 5q22.1

Cellular Component: cytoplasmic membrane-bound vesicle

NCBI Summary:Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]
UniProt Code:Q96DR4
NCBI GenInfo Identifier:25091316
NCBI Gene ID:134429
NCBI Accession:Q96DR4.1
UniProt Secondary Accession:Q96DR4,Q86TN9,
UniProt Related Accession:Q96DR4
Molecular Weight:18,517 Da
NCBI Full Name:StAR-related lipid transfer protein 4
NCBI Synonym Full Names:StAR related lipid transfer domain containing 4
NCBI Official Symbol:STARD4  
NCBI Protein Information:stAR-related lipid transfer protein 4
UniProt Protein Name:StAR-related lipid transfer protein 4
UniProt Synonym Protein Names:START domain-containing protein 4; StARD4
Protein Family:StAR-related lipid transfer protein
UniProt Gene Name:STARD4  
UniProt Entry Name:STAR4_HUMAN
Anti-STARD4 Antibody (CAB15955)Western blot analysis of extracts of various cell lines, using STARD4 antibody (CAB15955) at 1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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