Cell Biology Antibodies 9
Anti-ST6GAL1 Antibody (CAB5754)
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- SKU:
- CAB5754
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ST6GAL1 Antibody |
| Antibody SKU: | CAB5754 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-200 of human ST6GAL1 (NP_775323.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse thymus, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-200 of human ST6GAL1 (NP_775323.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KEKK KGSY YDSF KLQT KEFQ VLKS LGKL AMGS DSQS VSSS STQD PHRG RQTL GSLR GLAK AKPE ASFQ VWNK DSSS KNLI PRLQ KIWK NYLS MNKY KVSY KGPG PGIK FSAE ALRC HLRD HVNV SMVE VTDF PFNT SEWE GYLP KESI RTKA GPWG RCAV VSSA GSLK SSQL GR |
| Gene ID: | 6480 |
| Uniprot: | P15907 |
| Cellular Location: | Golgi apparatus, Golgi stack membrane, Secreted, Single-pass type II membrane protein |
| Calculated MW: | 20kDa/46kDa |
| Observed MW: | 47kDa |
| Synonyms: | ST6GAL1, SIAT1, ST6GalI, ST6N |
| Background: | This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. |
| UniProt Protein Function: | SIAT1: a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. Is normally found in the trans cisternae of the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. This protein is a member of glycosyltransferase family 29. Three transcript variants encoding two different isoforms have been found. |
| UniProt Protein Details: | Protein type:EC 2.4.99.1; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Transferase Chromosomal Location of Human Ortholog: 3q27.3 Cellular Component: Golgi membrane Molecular Function:beta-galactoside alpha-2,6-sialyltransferase activity; protein binding; sialyltransferase activity Biological Process: humoral immune response; N-acetylneuraminate metabolic process; O-glycan processing; oligosaccharide metabolic process; protein amino acid N-linked glycosylation via asparagine |
| NCBI Summary: | This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq, Aug 2009] |
| UniProt Code: | P15907 |
| NCBI GenInfo Identifier: | 115445 |
| NCBI Gene ID: | 6480 |
| NCBI Accession: | P15907.1 |
| UniProt Secondary Accession: | P15907,A8KA14, B2R513, D3DNV3, |
| UniProt Related Accession: | P15907 |
| Molecular Weight: | 47kDa |
| NCBI Full Name: | Beta-galactoside alpha-2,6-sialyltransferase 1 |
| NCBI Synonym Full Names: | ST6 beta-galactoside alpha-2,6-sialyltransferase 1 |
| NCBI Official Symbol: | ST6GAL1 |
| NCBI Official Synonym Symbols: | ST6N; SIAT1; ST6GalI |
| NCBI Protein Information: | beta-galactoside alpha-2,6-sialyltransferase 1 |
| UniProt Protein Name: | Beta-galactoside alpha-2,6-sialyltransferase 1 |
| UniProt Synonym Protein Names: | B-cell antigen CD75; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; ST6GalI; Sialyltransferase 1 |
| Protein Family: | Beta-galactoside alpha-2,6-sialyltransferase |
| UniProt Gene Name: | ST6GAL1 |
 | Western blot analysis of extracts of various cell lines, using ST6GAL1 antibody (CAB5754) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human stomach using ST6GAL1 antibody (CAB5754) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using ST6GAL1 antibody (CAB5754) at dilution of 1:100 (40x lens). |
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