Name: Anti-ST3GAL4 Antibody (CAB14491)
Brand: Cell Biology Antibodies 5
SKU: CAB14491
Availability: OutOfStock

Antibody Name:	Anti-ST3GAL4 Antibody
Antibody SKU:	CAB14491
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 125-329 of human ST3GAL4 (NP_006269.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse, Rat
Positive Samples:	Mouse brain, Rat brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 125-329 of human ST3GAL4 (NP_006269.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	LRNS SLGD AINK YDVV IRLN NAPV AGYE GDVG SKTT MRLF YPES AHFD PKVE NNPD TLLV LVAF KAMD FHWI ETIL SDKK RVRK GFWK QPPL IWDV NPKQ IRIL NPFF MEIA ADKL LSLP MQQP RKIK QKPT TGLL AITL ALHL CDLV HIAG FGYP DAYN KKQT IHYY EQIT LKSM AGSG HNVS QEAL AIKR MLEM GAIK NLTS F
Gene ID:	6484
Uniprot:	Q11206
Cellular Location:	Golgi apparatus, Golgi stack membrane, Secreted, Single-pass type II membrane protein
Calculated MW:	36kDa/37kDa/38kDa
Observed MW:	47kDa

Synonyms:

ST3GAL4, CGS23, NANTA3, SAT3, SIAT4, SIAT4C, ST-4, ST3GalA.2, ST3GalIV, STZ, gal-NAc6S

Background:

This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	ST3GAL4: It may catalyze the formation of the NeuAc-alpha-2,3- Gal-beta-1,3-GalNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding 1,3- galactosyl derivative. Belongs to the glycosyltransferase 29 family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral; EC 2.4.99.-; Glycan Metabolism - keratan sulfate biosynthesis; Transferase; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series Chromosomal Location of Human Ortholog: 11q24.2 Cellular Component: Golgi membrane; membrane Molecular Function:beta-galactoside alpha-2,3-sialyltransferase activity; monosialoganglioside sialyltransferase activity Biological Process: cognition; ganglioside biosynthetic process; keratan sulfate biosynthetic process; O-glycan processing; oligosaccharide metabolic process; protein amino acid N-linked glycosylation via asparagine
NCBI Summary:	This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:	Q11206
NCBI GenInfo Identifier:	1705565
NCBI Gene ID:	6484
NCBI Accession:	Q11206.1
UniProt Secondary Accession:	Q11206,O60497, Q8N6A6, Q8NFG7, Q96QQ9, A8K6B2,
UniProt Related Accession:	Q11206
Molecular Weight:	36,157 Da
NCBI Full Name:	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
NCBI Synonym Full Names:	ST3 beta-galactoside alpha-2,3-sialyltransferase 4
NCBI Official Symbol:	ST3GAL4
NCBI Official Synonym Symbols:	STZ; SAT3; CGS23; SIAT4; NANTA3; SIAT4C; ST3GalIV
NCBI Protein Information:	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
UniProt Protein Name:	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
UniProt Synonym Protein Names:	Alpha 2,3-sialyltransferase IV; Gal-NAc6S; Gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase; SAT-3; ST-4; ST3Gal IV; ST3GalIV; ST3GalA.2; STZ; Sialyltransferase 4C; SIAT4-C
Protein Family:	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase
UniProt Gene Name:	ST3GAL4
UniProt Entry Name:	SIA4C_HUMAN

Western blot analysis of extracts of various cell lines, using ST3GAL4 antibody (CAB14491) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 15s.

Antibodies

Anti-ST3GAL4 Antibody (CAB13544)

Anti-ST3GAL4 Antibody (CAB6309)

ST3GAL4 Antibody (PACO12487)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)