Cell Biology Antibodies 8

Anti-SSTR5 Antibody (CAB3136)

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SKU:
CAB3136
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SSTR5 Antibody
Antibody SKU:CAB3136
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 275-364 of human SSTR5 (NP_001044.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human
Positive Samples:HT-29
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 275-364 of human SSTR5 (NP_001044.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ALPQ EPAS AGLY FFVV ILSY ANSC ANPV LYGF LSDN FRQS FQKV LCLR KGSG AKDA DATE PRPD RIRQ QQEA TPPA HRAA ANGL MQTS KL
Gene ID:6755
Uniprot:P35346
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:39kDa
Observed MW:50kDa
Synonyms:SSTR5, SS-5-R
Background:Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.
UniProt Protein Function:SSTR5: Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; GPCR, family 1; Cell cycle regulation; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: neuron projection; integral to plasma membrane; plasma membrane

Molecular Function:neuropeptide binding; somatostatin receptor activity

Biological Process: positive regulation of cytokinesis; negative regulation of cell proliferation; G-protein signaling, coupled to cyclic nucleotide second messenger; synaptic transmission; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; glucose homeostasis; regulation of insulin secretion

Disease: Pituitary Adenoma, Growth Hormone-secreting

NCBI Summary:Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010]
UniProt Code:P35346
NCBI GenInfo Identifier:12644225
NCBI Gene ID:6755
NCBI Accession:P35346.3
UniProt Secondary Accession:P35346,P34988, Q541E0, Q9UJI5,
UniProt Related Accession:P35346,AAB31829
Molecular Weight:
NCBI Full Name:Somatostatin receptor type 5
NCBI Synonym Full Names:somatostatin receptor 5
NCBI Official Symbol:SSTR5  
NCBI Official Synonym Symbols:SS-5-R  
NCBI Protein Information:somatostatin receptor type 5; somatostatin receptor subtype 5
UniProt Protein Name:Somatostatin receptor type 5
UniProt Gene Name:SSTR5  
UniProt Entry Name:SSR5_HUMAN
Anti-SSTR5 Antibody (CAB3136)Western blot analysis of extracts of HT-29 cells, using SSTR5 antibody (CAB3136) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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