Name: Anti-SSTR4 Antibody (CAB6988)
Brand: Cell Biology Antibodies 10
SKU: CAB6988
Availability: OutOfStock

Antibody Name:	Anti-SSTR4 Antibody
Antibody SKU:	CAB6988
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 314-388 of human SSTR4 (NP_001043.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	HL-60, BT-474, HepG2, Mouse brain, Rat brain, Rat lung

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 314-388 of human SSTR4 (NP_001043.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	LSDN FRRF FQRV LCLR CCLL EGAG GAEE EPLD YYAT ALKS KGGA GCMC PPLP CQQE ALQP EPGR KRIP LTRT TTF
Gene ID:	6754
Uniprot:	P31391
Cellular Location:	Cell membrane, Multi-pass membrane protein
Calculated MW:	42kDa
Observed MW:	39kDa

Synonyms:

SSTR4, SS-4-R, SS4-R, SS4R

Background:

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.

UniProt Protein Function:	SSTR4: Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:	Protein type:GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 20p11.2 Cellular Component: cytoplasm; integral to plasma membrane; neuron projection; plasma membrane Molecular Function:neuropeptide binding; somatostatin receptor activity Biological Process: arachidonic acid metabolic process; cell migration; forebrain development; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of cAMP metabolic process; negative regulation of cell proliferation; positive regulation of MAPKKK cascade
NCBI Summary:	Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]
UniProt Code:	P31391
NCBI GenInfo Identifier:	206729897
NCBI Gene ID:	6754
NCBI Accession:	P31391.2
UniProt Secondary Accession:	P31391,Q17RM1, Q17RM3, Q9UIY1,
UniProt Related Accession:	P31391
Molecular Weight:	42,003 Da
NCBI Full Name:	Somatostatin receptor type 4
NCBI Synonym Full Names:	somatostatin receptor 4
NCBI Official Symbol:	SSTR4
NCBI Official Synonym Symbols:	SS4R; SS4-R; SS-4-R
NCBI Protein Information:	somatostatin receptor type 4
UniProt Protein Name:	Somatostatin receptor type 4
Protein Family:	Somatostatin receptor
UniProt Gene Name:	SSTR4
UniProt Entry Name:	SSR4_HUMAN

Western blot analysis of extracts of various cell lines, using SSTR4 antibody (CAB6988) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 300s.

Antibodies

SSTR4 Antibody (PACO05134)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)