Cell Biology Antibodies 6

Anti-SSTR3 Antibody (CAB16071)

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SKU:
CAB16071
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-SSTR3 Antibody
Antibody SKU:CAB16071
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 250-350 of human SSTR3 (NP_001042.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, LO2, Mouse brain, Rat brain, Rat spleen
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 250-350 of human SSTR3 (NP_001042.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RSER RVTR MVVA VVAL FVLC WMPF YVLN IVNV VCPL PEEP AFFG LYFL VVAL PYAN SCAN PILY GFLS YRFK QGFR RVLL RPSR RVRS QEPT VGPP EKTE E
Gene ID:6753
Uniprot:P32745
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:45kDa
Observed MW:46kDa
Synonyms:SSTR3, SS-3-R, SS3-R, SS3R, SSR-28
Background:This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:SSTR3: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: neuron projection; nonmotile primary cilium; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function:neuropeptide binding; somatostatin receptor activity; protein binding

Biological Process: response to starvation; synaptic transmission; negative regulation of cell proliferation; G-protein signaling, coupled to cyclic nucleotide second messenger; cell-cell signaling; neuropeptide signaling pathway; induction of apoptosis by hormones; organelle organization and biogenesis; forebrain development; cerebellum development; spermatogenesis; regulation of insulin secretion

NCBI Summary:This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:P32745
NCBI GenInfo Identifier:4557861
NCBI Gene ID:6753
NCBI Accession:NP_001042.1
UniProt Secondary Accession:P32745,Q53ZR7, A8K550,
UniProt Related Accession:P32745
Molecular Weight:45,847 Da
NCBI Full Name:somatostatin receptor type 3
NCBI Synonym Full Names:somatostatin receptor 3
NCBI Official Symbol:SSTR3  
NCBI Official Synonym Symbols:SS3R; SS3-R; SS-3-R; SSR-28  
NCBI Protein Information:somatostatin receptor type 3
UniProt Protein Name:Somatostatin receptor type 3
UniProt Synonym Protein Names:SSR-28
UniProt Gene Name:SSTR3  
UniProt Entry Name:SSR3_HUMAN
Anti-SSTR3 Antibody (CAB16071)Western blot analysis of extracts of various cell lines, using SSTR3 antibody (CAB16071) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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