Cell Biology Antibodies 8
Anti-SSTR2 Antibody (CAB3135)
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- SKU:
- CAB3135
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-SSTR2 Antibody |
| Antibody SKU: | CAB3135 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human SSTR2 (NP_001041.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, mouse eye, mouse liver, rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human SSTR2 (NP_001041.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LTYA NSCA NPIL YAFL SDNF KKSF QNVL CLVK VSGT DDGE RSDS KQDK SRLN ETTE TQRT LLNG DLQT SI |
| Gene ID: | 6752 |
| Uniprot: | P30874 |
| Cellular Location: | Cell membrane, Cytoplasm, Multi-pass membrane protein |
| Calculated MW: | 40kDa/41kDa |
| Observed MW: | 56kDa |
| Synonyms: | SSTR2, somatostatin receptor 2, SS 2 R, SS2R, SRIF 1, SS2 R, SRIF-1 |
| Background: | Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. |
| UniProt Protein Function: | SSTR2: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. The C-terminus interacts with SHANK1 PDZ domain. Cerebrum and kidney. In lesser amounts in jejunum, colon and liver. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 17q24 Cellular Component: neuron projection; integral to plasma membrane; cytoplasm; plasma membrane Molecular Function:neuropeptide binding; protein binding; somatostatin receptor activity; PDZ domain binding Biological Process: peristalsis; regulation of muscle contraction; response to starvation; synaptic transmission; negative regulation of cell proliferation; G-protein signaling, coupled to cyclic nucleotide second messenger; cell-cell signaling; neuropeptide signaling pathway; forebrain development; digestion; cerebellum development; spermatogenesis; G-protein signaling, adenylate cyclase inhibiting pathway; response to nutrient |
| NCBI Summary: | Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P30874 |
| NCBI GenInfo Identifier: | 401126 |
| NCBI Gene ID: | 6752 |
| NCBI Accession: | P30874.1 |
| UniProt Secondary Accession: | P30874,Q4VBP0, Q96GE0, Q96TF2, Q9BWH1, A8K3Y0, B2R9P7 |
| UniProt Related Accession: | P30874 |
| Molecular Weight: | 369 |
| NCBI Full Name: | Somatostatin receptor type 2 |
| NCBI Synonym Full Names: | somatostatin receptor 2 |
| NCBI Official Symbol: | SSTR2 |
| NCBI Protein Information: | somatostatin receptor type 2; SS2R; SRIF-1 |
| UniProt Protein Name: | Somatostatin receptor type 2 |
| UniProt Synonym Protein Names: | SRIF-1 |
| UniProt Gene Name: | SSTR2 |
| UniProt Entry Name: | SSR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SSTR2 antibody (CAB3135) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human stomach using SSTR2 antibody (CAB3135) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver damage using SSTR2 antibody (CAB3135) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U-2 OS cells using SSTR2 Polyclonal Antibody (CAB3135) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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