Cell Biology Antibodies 11

Anti-SSR4 Antibody (CAB8037)

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SKU:
CAB8037
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:SSR4 Rabbit Polyclonal Antibody
Antibody SKU:CAB8037
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-144 of human SSR4 (NP_006271.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse
Positive Samples:LO2, U-87MG, MCF7, HL-60, Mouse liver, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-144 of human SSR4 (NP_006271.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EACL EPQI TPSY YTTS DAVI STET VFIV EISL TCKN RVQN MALY ADVG GKQF PVTR GQDV GRYQ VSWS LDHK SAHA GTYE VRFF DEES YSLL RKAQ RNNE DISI IPPL FTVS VDHR GTWN G
Gene ID:6748
Uniprot:P51571
Cellular Location:Endoplasmic reticulum membrane, Single-pass type I membrane protein
Calculated MW:18kDa
Observed MW:19kDa
Synonyms:SSR4, CDG1Y, TRAPD
Background:This gene encodes the delta subunit of the translocon-associated protein complex which is involved in translocating proteins across the endoplasmic reticulum membrane. The encoded protein is located in the Xq28 region and is arranged in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene and both genes are driven by a CpG-embedded bidirectional promoter. Alternate splicing results in multiple transcript variants.
UniProt Protein Function:SSR4: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. Belongs to the TRAP-delta family.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28

Disease: Congenital Disorder Of Glycosylation, Type Iy

NCBI Summary:This gene encodes the delta subunit of the translocon-associated protein complex which is involved in translocating proteins across the endoplasmic reticulum membrane. The encoded protein is located in the Xq28 region and is arranged in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene and both genes are driven by a CpG-embedded bidirectional promoter. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]
UniProt Code:P51571
NCBI GenInfo Identifier:1711550
NCBI Gene ID:6748
NCBI Accession:P51571.1
UniProt Secondary Accession:P51571,Q53XY1, A8K378,
UniProt Related Accession:P51571
Molecular Weight:18,999 Da
NCBI Full Name:Translocon-associated protein subunit delta
NCBI Synonym Full Names:signal sequence receptor subunit 4
NCBI Official Symbol:SSR4  
NCBI Official Synonym Symbols:CDG1Y; TRAPD  
NCBI Protein Information:translocon-associated protein subunit delta
UniProt Protein Name:Translocon-associated protein subunit delta
UniProt Synonym Protein Names:Signal sequence receptor subunit delta; SSR-delta
Protein Family:SWI/SNF and RSC complexes
UniProt Gene Name:SSR4  
UniProt Entry Name:SSRD_HUMAN
Anti-SSR4 Polyclonal Antibody (CAB8037)Western blot analysis of extracts of various cell lines, using SSR4 antibody (CAB8037) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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