Epigenetics & Nuclear Signaling Antibodies 3

Anti-SSR3 Antibody (CAB17873)

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SKU:
CAB17873
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-SSR3 Antibody
Antibody SKU:CAB17873
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 70-145 of human SSR3 (NP_009038.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, K-562, BxPC-3, HeLa, mouse pancreas, mouse uterus, rat pancreas, rat uterus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 70-145 of human SSR3 (NP_009038.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TYLV AFAY KNVK FVLK HKVA QKRE DAVS KEVT RKLS EADN RKMS RKEK DERI LWKK NEVA DYEA TTFS IFYN NTLF
Gene ID:6747
Uniprot:Q9UNL2
Cellular Location:
Calculated MW:21kDa
Observed MW:21kDa
Synonyms:TRAPG, SSR3
Background:The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times.
UniProt Protein Function:SSR3: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. Belongs to the TRAP-gamma family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q25.31

Cellular Component: integral to endoplasmic reticulum membrane; translocon complex

Biological Process: SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translation; gene expression

NCBI Summary:The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]
UniProt Code:Q9UNL2
NCBI GenInfo Identifier:9087205
NCBI Gene ID:6747
NCBI Accession:Q9UNL2.1
UniProt Related Accession:Q9UNL2
Molecular Weight:21kDa
NCBI Full Name:Translocon-associated protein subunit gamma
NCBI Synonym Full Names:signal sequence receptor subunit 3
NCBI Official Symbol:SSR3  
NCBI Official Synonym Symbols:TRAPG  
NCBI Protein Information:translocon-associated protein subunit gamma
UniProt Protein Name:Translocon-associated protein subunit gamma
UniProt Synonym Protein Names:Signal sequence receptor subunit gamma; SSR-gamma
Protein Family:SWI/SNF and RSC complexes
UniProt Gene Name:SSR3  
UniProt Entry Name:SSRG_HUMAN
Anti-SSR3 Antibody (CAB17873)Western blot analysis of extracts of various cells, using SSR3 antibody (CAB17873) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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