Epigenetics & Nuclear Signaling Antibodies 4
Anti-SS18 Antibody (CAB6990)
(No reviews yet)
Write a Review
- SKU:
- CAB6990
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-SS18 Antibody |
| Antibody SKU: | CAB6990 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human SS18 (NP_001007560.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | MCF7, Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human SS18 (NP_001007560.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSVA FAAP RQRG KGEI TPAA IQKM LDDN NHLI QCIM DSQN KGKT SECS QYQQ MLHT NLVY LATI ADSN QNMQ SLLP APPT QNMP MGPG GMNQ SGPP PPPR SHNM PSDG MVGG GPPA PHMQ NQMN GQMP GPNH MPMQ GPGP NQLN MTNS SMNM PSSS HGSM GGYN HSVP SSQS MPVQ NQMT MSQG QPMG NYGP RPNM SMQP NQGP MMHQ QPPS QQYN MPQG GGQH YQGQ QPPM GMMG QVNQ |
| Gene ID: | 6760 |
| Uniprot: | Q15532 |
| Cellular Location: | Nucleus |
| Calculated MW: | 42kDa/45kDa |
| Observed MW: | 60kDa |
| Synonyms: | SS18, SSXT, SYT |
| Background: |
| UniProt Protein Function: | SS18: Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency). Belongs to the SS18 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oncoprotein; Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 18q11.2 Cellular Component: cytoplasmic microtubule; nucleus Molecular Function:protein binding; ligand-dependent nuclear receptor transcription coactivator activity Biological Process: response to drug; transcription, DNA-dependent; cell morphogenesis; ephrin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; microtubule cytoskeleton organization and biogenesis |
| UniProt Code: | Q15532 |
| NCBI GenInfo Identifier: | 20141795 |
| NCBI Gene ID: | 6760 |
| NCBI Accession: | Q15532.3 |
| UniProt Secondary Accession: | Q15532,Q16404, Q4VAX1, Q9BXC6, B0YJ95, |
| UniProt Related Accession: | Q15532 |
| Molecular Weight: | 418 |
| NCBI Full Name: | Protein SSXT |
| NCBI Synonym Full Names: | synovial sarcoma translocation, chromosome 18 |
| NCBI Official Symbol: | SS18 |
| NCBI Official Synonym Symbols: | SYT; SSXT |
| NCBI Protein Information: | protein SSXT; synovial sarcoma, translocated to X chromosome; synovial sarcoma translocated to X chromosome protein |
| UniProt Protein Name: | Protein SSXT |
| UniProt Synonym Protein Names: | Protein SYT; Synovial sarcoma translocated to X chromosome protein |
| Protein Family: | SS18-like protein |
| UniProt Gene Name: | SS18 |
| UniProt Entry Name: | SSXT_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SS18 antibody (CAB6990) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using SS18 antibody (CAB6990) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of MCF7 cells using SS18 antibody (CAB6990). |
View AllClose
Related Products
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
Human Anti-DSG3 antibody(anti-Desmoglein-3 antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक