Epigenetics & Nuclear Signaling Antibodies 3

Anti-SRSF6 Antibody (CAB14603)

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SKU:
CAB14603
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-SRSF6 Antibody
Antibody SKU:CAB14603
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SRSF6 (NP_006266.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, K562, HeLa, HepG2
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SRSF6 (NP_006266.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPRV YIGR LSYN VREK DIQR FFSG YGRL LEVD LKNG YGFV EFED SRDA DDAV YELN GKEL CGER VIVE HARG PRRD RDGY SYGS RSGG GGYS SRRT SGRD
Gene ID:6431
Uniprot:Q13247
Cellular Location:Nucleus, Nucleus speckle
Calculated MW:15kDa/38kDa/39kDa
Observed MW:55kDa
Synonyms:SRSF6, B52, HEL-S-91, SFRS6, SRP55
Background:The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.
UniProt Protein Function:Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.
NCBI Summary:The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010]
UniProt Code:Q13247
NCBI GenInfo Identifier:20127499
NCBI Gene ID:6431
NCBI Accession:NP_006266.2
UniProt Secondary Accession:Q13247,Q13244, Q13245, Q96J06, Q9UJB8, Q9Y3N7, B7Z6J3 E1P5W6,
UniProt Related Accession:Q13247
Molecular Weight:Calculated: 15kDa; 38kDa; 39kDaObserved: 55kDa
NCBI Full Name:serine/arginine-rich splicing factor 6
NCBI Synonym Full Names:serine and arginine rich splicing factor 6
NCBI Official Symbol:SRSF6  
NCBI Official Synonym Symbols:B52; SFRS6; SRP55; HEL-S-91  
NCBI Protein Information:serine/arginine-rich splicing factor 6
UniProt Protein Name:Serine/arginine-rich splicing factor 6
UniProt Synonym Protein Names:Pre-mRNA-splicing factor SRP55; Splicing factor, arginine/serine-rich 6
Protein Family:Serine/arginine-rich splicing factor
UniProt Gene Name:SRSF6  
Anti-SRSF6 Antibody (CAB14603)Western blot analysis of extracts of various cell lines, using SRSF6 antibody (CAB14603) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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